CD14 基因的多态性可能会改变可溶性 CD14 的水平,并代表多发性硬化症的风险因素。

IF 2.9 4区 医学 Q3 IMMUNOLOGY Immunological Investigations Pub Date : 2024-05-01 Epub Date: 2016-11-07 DOI:10.1080/08820139.2016.1226897
Mehrdad Farrokhi, Pedram Moeini, Mohammad Fazilati, Habibollah Nazem, Shahla Faraji, Zahra Saadatpour, Elyas Fadaei, Leila Saadatpour, Ali Rezaei, Sadra Ansaripour, Ali Amani-Beni
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引用次数: 0

摘要

背景:除了适应性免疫系统的核心作用外,先天性免疫系统紊乱也被认为与多发性硬化症(MS)的发病机制有关。CD14 是活化的小胶质细胞中上调的受体,已知是先天性免疫反应中炎症的重要介质。因此,在本研究中,我们旨在评估 CD14-159 和 -260 基因多态性在多发性硬化症易感性中的可能作用,以及这些多态性对伊朗人群中 CD14 蛋白生成能力的影响:在这项病例对照研究中,使用聚合酶链式反应限制性片段长度多态性(PCR-RFLP)对200名多发性硬化症患者和200名年龄和性别匹配的健康对照者的CD14-159和-260多态性进行了基因分型。通过酶联免疫吸附试验(ELISA)测定血清中可溶性 CD14(sCD14)的水平:结果:患者和对照组的 CD14-159 和 -260 多态性基因型分布存在明显差异(P = 0.01,均为 0.01)。多发性硬化症患者血清中 sCD14 的平均水平明显高于对照组(3340.30 ± 612.50 ng/ml vs 2353.73 ± 539.07 ng/ml;P < 0.01):综上所述,我们得出结论:CD14-159 和 -260 多态性与伊朗人群罹患多发性硬化症的风险有关,并影响 CD14 启动子的活性,从而调节 CD14 的表达。此外,我们的研究还为先天性免疫在多发性硬化症发病机制中的激活提供了初步证据。此外,本研究的结果还表明,血清中的 sCD14 水平可作为多发性硬化症严重程度的候选生物标志物。
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RETRACTED ARTICLE: Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis.

Statement of RetractionWe, the Editors and Publisher of the journal Immunological Investigations, have retracted the following article:Merhdad Farrokhi, Pedram Moeini, Mohammada Fazilati, Habibollah Nazem, Shahla Faraji, Zahra Saadatpour, Elyas Fadaei, Leila Saadatpour, Ali Rezaei, Sadra Ansaripour and Ali Amani-Beni (2016) Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis, Immunological Investigations, DOI: https://doi.org/10.1080/08820139.2016.1226897Since publication, significant concerns have been raised about the author affiliations, ethical approval, and the integrity of the data in the article.When approached for an explanation, the authors provided responses to our queries regarding the flow cytometry data, but they have not sufficiently addressed all of our concerns. In particular, the authors and institution did not respond to our requests for proof that the research was conducted at the Isfahan University of Medical Sciences or provide proof of ethical approval.As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The corresponding author listed in this publication has been informed.We have been informed in our decision-making by our Editorial Policies and COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.

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来源期刊
Immunological Investigations
Immunological Investigations 医学-免疫学
CiteScore
5.50
自引率
7.10%
发文量
49
审稿时长
3 months
期刊介绍: Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.
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