孤立的快速眼动行为障碍的神经心理学特征的数据驱动方法:潜在类分析

IF 2 4区 心理学 Q2 PSYCHOLOGY Journal of Neuropsychology Pub Date : 2022-10-03 DOI:10.1111/jnp.12292
Samantha Mombelli, Caterina Leitner, Giada D'Este, Marco Sforza, Sara Marelli, Alessandra Castelnuovo, Marco Zucconi, Francesca Casoni, Maria Livia Fantini, Fabiana Novellino, Maria Salsone, Luigi Ferini-Strambi, Andrea Galbiati
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引用次数: 0

摘要

最近的证据表明,神经心理学评估可能被认为是特发性快速眼动睡眠行为障碍(iRBD)神经退行性变的有效标志。然而,人们对iRBD人群中可能存在的神经心理异质性知之甚少。本回顾性研究旨在通过潜在类分析的数据驱动方法,识别和描述iRBD患者的不同神经心理表型。共有289名iRBD患者接受了神经心理学评估,评估认知领域:全球认知、语言、短期和长期记忆、执行功能和视觉空间能力。轻度认知障碍(MCI)的存在也被评估。根据神经心理学评分进行潜在分类分析,以确定iRBD亚型。最简洁的模型确定了三个潜在的类别。2级“严重受损”(n = 83/289):不同测试的平均病理评分,MCI多域百分比高,所有神经心理域损伤。1级“中度受损”(n = 44/289):平均神经心理学评分在正常值范围内,MCI(表型转化高风险)百分比高,视觉空间领域严重受损。3级“轻度受损”(n = 162/289):除了短期和长期记忆外,没有值得注意的缺陷。我们的研究结果表明,iRBD人群中存在三种不同的临床表型。这些发现可能与未来预测iRBD表型转化的临床轨迹有关。
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A data-driven approach to neuropsychological features in isolated REM behaviour disorder: A latent class analysis

Recent evidence demonstrated that neuropsychological assessment may be considered a valid marker of neurodegeneration in idiopathic REM sleep behaviour disorder (iRBD). However, little is known about the possible neuropsychological heterogeneity within the iRBD population. This retrospective study aimed to identify and describe different neuropsychological phenotypes in iRBD patients by means of a data-driven approach using latent class analysis. A total of 289 iRBD patients underwent a neuropsychological assessment evaluating cognitive domains: global cognition, language, short- and long-term memory, executive functions and visuospatial abilities. The presence of mild cognitive impairment (MCI) was also assessed. Latent class analysis was carried out to identify iRBD subtypes according to neuropsychological scores. The most parsimonious model identified three latent classes. Groups were labelled as follows: Class 2 “severely impaired” (n = 83/289): mean pathological scores in different tests, a high percentage of MCI multiple-domain and impairment in all neuropsychological domains. Class 1 “moderately impaired” (n = 44/289): mean neuropsychological score within the normal value, a high percentage of MCI (high risk to phenoconversion) and great impairment in the visuospatial domain. Class 3 “slightly impaired” (n = 162/289): no deficit worthy of attention except for short- and long-term memory. Our results suggest three different clinical phenotypes within the iRBD population. These findings may be relevant in the future for predicting the clinical trajectories of phenoconversion in iRBD.

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来源期刊
Journal of Neuropsychology
Journal of Neuropsychology 医学-心理学
CiteScore
4.50
自引率
4.50%
发文量
34
审稿时长
>12 weeks
期刊介绍: The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.
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