Samantha Mombelli, Caterina Leitner, Giada D'Este, Marco Sforza, Sara Marelli, Alessandra Castelnuovo, Marco Zucconi, Francesca Casoni, Maria Livia Fantini, Fabiana Novellino, Maria Salsone, Luigi Ferini-Strambi, Andrea Galbiati
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A total of 289 iRBD patients underwent a neuropsychological assessment evaluating cognitive domains: global cognition, language, short- and long-term memory, executive functions and visuospatial abilities. The presence of mild cognitive impairment (MCI) was also assessed. Latent class analysis was carried out to identify iRBD subtypes according to neuropsychological scores. The most parsimonious model identified three latent classes. Groups were labelled as follows: Class 2 “severely impaired” (<i>n</i> = 83/289): mean pathological scores in different tests, a high percentage of MCI multiple-domain and impairment in all neuropsychological domains. Class 1 “moderately impaired” (<i>n</i> = 44/289): mean neuropsychological score within the normal value, a high percentage of MCI (high risk to phenoconversion) and great impairment in the visuospatial domain. Class 3 “slightly impaired” (<i>n</i> = 162/289): no deficit worthy of attention except for short- and long-term memory. Our results suggest three different clinical phenotypes within the iRBD population. These findings may be relevant in the future for predicting the clinical trajectories of phenoconversion in iRBD.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A data-driven approach to neuropsychological features in isolated REM behaviour disorder: A latent class analysis\",\"authors\":\"Samantha Mombelli, Caterina Leitner, Giada D'Este, Marco Sforza, Sara Marelli, Alessandra Castelnuovo, Marco Zucconi, Francesca Casoni, Maria Livia Fantini, Fabiana Novellino, Maria Salsone, Luigi Ferini-Strambi, Andrea Galbiati\",\"doi\":\"10.1111/jnp.12292\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Recent evidence demonstrated that neuropsychological assessment may be considered a valid marker of neurodegeneration in idiopathic REM sleep behaviour disorder (iRBD). 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Class 1 “moderately impaired” (<i>n</i> = 44/289): mean neuropsychological score within the normal value, a high percentage of MCI (high risk to phenoconversion) and great impairment in the visuospatial domain. Class 3 “slightly impaired” (<i>n</i> = 162/289): no deficit worthy of attention except for short- and long-term memory. Our results suggest three different clinical phenotypes within the iRBD population. 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A data-driven approach to neuropsychological features in isolated REM behaviour disorder: A latent class analysis
Recent evidence demonstrated that neuropsychological assessment may be considered a valid marker of neurodegeneration in idiopathic REM sleep behaviour disorder (iRBD). However, little is known about the possible neuropsychological heterogeneity within the iRBD population. This retrospective study aimed to identify and describe different neuropsychological phenotypes in iRBD patients by means of a data-driven approach using latent class analysis. A total of 289 iRBD patients underwent a neuropsychological assessment evaluating cognitive domains: global cognition, language, short- and long-term memory, executive functions and visuospatial abilities. The presence of mild cognitive impairment (MCI) was also assessed. Latent class analysis was carried out to identify iRBD subtypes according to neuropsychological scores. The most parsimonious model identified three latent classes. Groups were labelled as follows: Class 2 “severely impaired” (n = 83/289): mean pathological scores in different tests, a high percentage of MCI multiple-domain and impairment in all neuropsychological domains. Class 1 “moderately impaired” (n = 44/289): mean neuropsychological score within the normal value, a high percentage of MCI (high risk to phenoconversion) and great impairment in the visuospatial domain. Class 3 “slightly impaired” (n = 162/289): no deficit worthy of attention except for short- and long-term memory. Our results suggest three different clinical phenotypes within the iRBD population. These findings may be relevant in the future for predicting the clinical trajectories of phenoconversion in iRBD.
期刊介绍:
The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including:
• clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups
• behavioural or pharmacological treatment regimes
• cognitive experimentation and neuroimaging
• multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science
The following types of paper are invited:
• papers reporting original empirical investigations
• theoretical papers; provided that these are sufficiently related to empirical data
• review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications
• brief reports and comments
• case reports
• fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors)
• special issues.