炎症性呼吸道疾病坏死的细胞类型特异性分子机制和意义。

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2023-10-28 DOI:10.1111/imr.13282
Ying Guo, Jin Zhou, Yaqi Wang, Xueliang Wu, Yakui Mou, Xicheng Song
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引用次数: 0

摘要

坏死通常被认为是一种炎症细胞死亡形式。坏死信号传导的核心调节因子是受体相互作用的丝氨酸-苏氨酸蛋白激酶1(RIPK1)和RIPK3,以及执行者混合谱系激酶结构域样假激酶(MLKL)。有证据表明,坏死对常见的公共卫生问题炎症性呼吸道疾病有着深刻的影响。在炎症性呼吸道疾病的环境中,几乎所有类型的肺细胞都会发生坏死。坏死对细胞的影响因细胞、组织、器官等的类型而异,这是一个需要考虑的重要因素。因此,在这篇综述中,我们简要总结了坏死生物学的最新知识,并重点介绍了定义炎症性呼吸道疾病中特定细胞类型坏死状态的关键分子机制。我们还讨论了坏死小分子抑制剂在治疗炎症性呼吸道疾病中的临床潜力,并描述了在呼吸道炎症的背景下,坏死和其他细胞死亡途径之间相互作用的病理过程。单细胞技术的快速进步将有助于了解细胞类型特异性坏死的关键机制,这些机制对有效治疗致病性肺部感染和炎症性呼吸道疾病至关重要。
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Cell type-specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases

Necroptosis is generally considered as an inflammatory cell death form. The core regulators of necroptotic signaling are receptor-interacting serine–threonine protein kinases 1 (RIPK1) and RIPK3, and the executioner, mixed lineage kinase domain-like pseudokinase (MLKL). Evidence demonstrates that necroptosis contributes profoundly to inflammatory respiratory diseases that are common public health problem. Necroptosis occurs in nearly all pulmonary cell types in the settings of inflammatory respiratory diseases. The influence of necroptosis on cells varies depending upon the type of cells, tissues, organs, etc., which is an important factor to consider. Thus, in this review, we briefly summarize the current state of knowledge regarding the biology of necroptosis, and focus on the key molecular mechanisms that define the necroptosis status of specific cell types in inflammatory respiratory diseases. We also discuss the clinical potential of small molecular inhibitors of necroptosis in treating inflammatory respiratory diseases, and describe the pathological processes that engage cross talk between necroptosis and other cell death pathways in the context of respiratory inflammation. The rapid advancement of single-cell technologies will help understand the key mechanisms underlying cell type-specific necroptosis that are critical to effectively treat pathogenic lung infections and inflammatory respiratory diseases.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
期刊最新文献
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