Bone-regeneration Trial of Rat Critical-size Calvarial Defects using Nano-apatite/collagen Composites

95 Introduction The development of new alloplastic bone graft materials is now expected in dentistry, as well as orthopedic surgery, to improve the quality of clinical treatment (e.g., sinus lift elevation for dental implantology) [1]. Apatite is an osteo-conductive material, and large apatite plate and granules (blocks) have been employed as artificial bone skull [2] and bone-filling materials [3], respectively. These apatite devices have the large dimension of about 100 m to several cm [2, 3]. On the other hand, nano-apatite has recently attracted the attention in bio-materials community. Apatite drastically changes physical, Bone-regeneration Trial of Rat Critical-size Calvarial Defects using Nano-apatite/collagen Composites