钙通道阻滞剂引起牙龈过度生长的发生率

Q4 Pharmacology, Toxicology and Pharmaceutics Oral Therapeutics and Pharmacology Pub Date : 2008-08-01 DOI:10.11263/JSOTP1982.27.79

M. Ono, Naoko Ohno, K. Hasegawa, Shigeo Tanaka, M. Komiya, H. Matsumoto, A. Fujii, Y. Akimoto

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引用次数: 9

摘要

测定钙通道阻滞剂引起的牙龈过度生长的发生率。在使用氨氯地平、地尔硫卓、曼尼地平、尼卡地平、硝苯地平和尼索地平的患者中发现过度生长。牙龈过度生长率最高的是硝苯地平(7.6%)，其次是地尔硫卓(4.1%)、曼尼地平(1.8%)、氨氯地平(1.1%)、尼索地平(1.1%)和尼卡地平(0.5%)。硝苯地平引起的牙龈过度生长率显著高于氨氯地平、曼尼地平、尼卡地平和尼索地平，但不高于地尔硫卓。

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Incidence of gingival overgrowth caused by calcium channel blockers

The incidence of gingival overgrowth caused by calcium channel blockers was determined. The overgrowth was found in patients receiving amlodipine, diltiazem, manidipine, nicardipine, nifedipine and nisoldipine. The highest rate of gingival overgrowth was obtained by nifedipine (7.6%), followed by diltiazem (4.1%), manidipine (1.8%), amlodipine (1.l%), nisoldipine (1.1%) and nicardipine (0.5%). The rate of nifedipine-induced gingival overgrowth was significantly higher than those of amlodipine, manidipine, nicardipine and nisoldipine, but not diltiazem.

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