埃及家族性地中海热患儿血清淀粉样蛋白A水平

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2016-12-13 DOI:10.1155/2016/7354018
Hala M Lofty, H. Marzouk, Y. Farag, M. Nabih, Iman Khalifa, Noha Mostafa, A. Salah, L. Rashed, Kamal El Garf
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引用次数: 16

摘要

背景和目标。SAA是在FMF发作或其他炎症条件下检测到的急性期反应物。高SAA水平可能会增加淀粉样变的风险。该研究的目的是测量一组患有家族性地中海热(FMF)的埃及儿童的血清淀粉样蛋白A (SAA)水平,并研究其各种相关因素,如果有的话。方法。该研究招募了71名患有FMF的儿童。结果。78.9%的患者SAA水平较高,平均为81.62±31.6 mg/L, 31%的患者CRP呈阳性。SAA水平与任何人口统计学或临床表现之间无显著相关性。高SAA以V726A等位基因最多(16.9%),其次是M694V等位基因(12.3%)。低剂量秋水仙碱患者SAA水平升高更为常见。45%的患者对秋水仙碱治疗的依从性较低。解释与结论。在最后一次FMF发作两周后,在很大比例的埃及FMF儿童中检测到高SAA水平。这表明在无发作期亚临床炎症仍在继续,SAA可作为其标志物。
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Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever
Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. Interpretation and Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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