基线血清肌酐对重症狼疮肾炎患者完全缓解率和长期预后的影响

Nephron Extra Pub Date : 2016-08-18 eCollection Date: 2016-05-01 DOI:10.1159/000448487
Stephen M Korbet, William L Whittier, Edmund J Lewis
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引用次数: 0

摘要

背景/目的:我们评估了基线血清肌酐对重症狼疮性肾炎(SLN)完全缓解率和长期预后的影响:根据基线血清肌酐水平(分别为≤1.0、1.01-1.5、1.51-2.0、2.01-3.0和>3.0 mg/dl;n=22、23、16、12和13)评估了86名重症狼疮性肾炎(SLN)[国际肾脏病学会/肾脏病理学会(ISN/RPS)IV级病变]成年患者。比较了完全缓解率(血清肌酐水平≤1.4 mg/dl,蛋白尿≤0.33 g/天)和长期疗效(肾功能稳定、透析和死亡)。对患者进行了 121 ± 64 个月的随访:结果:基线临床特征相似,但随着血清肌酐水平的升高,慢性化指数明显升高。血清肌酐水平较低的患者完全缓解率明显更高(86 vs. 52 vs. 19 vs. 25 vs. 0%,P < 0.0001)。与血清肌酐水平>1.0 mg/dl的患者相比,基线血清肌酐水平≤1.0 mg/dl的患者获得完全缓解的几率是后者的16倍(OR 16.2;95% CI:4.2-61.5),最后一次随访时肾功能稳定的几率是后者的6倍(OR 6.1;95% CI:1.9-18.6)。基线血清肌酐水平≤1.0 mg/dl的患者15年肾功能存活率最高(76 vs. 57 vs. 48 vs. 25 vs. 10%, p < 0.0001):SLN的预后受基线血清肌酐水平的显著影响。基线血清肌酐水平≤1.0 mg/dl的患者完全缓解率最高,长期预后最有利。这强调了早期诊断和治疗的重要性。
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The Impact of Baseline Serum Creatinine on Complete Remission Rate and Long-Term Outcome in Patients with Severe Lupus Nephritis.

Background/aim: We assess the impact of serum creatinine at baseline on complete remission rate and long-term outcome in severe lupus nephritis (SLN).

Methods: A total of 86 adult patients with SLN [International Society of Nephrology/Renal Pathology Society (ISN/RPS) class IV lesions] were evaluated based on baseline serum creatinine levels (≤1.0, 1.01-1.5, 1.51-2.0, 2.01-3.0, and >3.0 mg/dl; n = 22, 23, 16, 12, and 13, respectively). The complete remission rates (serum creatinine level of ≤1.4 mg/dl and proteinuria of ≤0.33 g/day) and long-term outcomes (stable renal function, dialysis, and death) were compared. The patients were followed for 121 ± 64 months.

Results: The baseline clinical features were similar, but the chronicity index was significantly higher with increasing levels of serum creatinine. Complete remission rates were significantly higher in patients with lower levels of serum creatinine (86 vs. 52 vs. 19 vs. 25 vs. 0%, p < 0.0001). Patients with a baseline serum creatinine level of ≤1.0 mg/dl were >16 times as likely (OR 16.2; 95% CI: 4.2-61.5) to attain a complete remission and >6 times as likely (OR 6.1; 95% CI: 1.9-18.6) to have stable renal function at the last follow-up as compared to patients with a serum creatinine level of >1.0 mg/dl. The 15-year renal survival rate was greatest among those patients with a baseline serum creatinine level of ≤1.0 mg/dl (76 vs. 57 vs. 48 vs. 25 vs. 10%, p < 0.0001).

Conclusion: The prognosis of SLN is significantly affected by the serum creatinine level at baseline. The complete remission rate is highest, and the long-term prognosis most favorable, in patients with a baseline serum creatinine level of ≤1.0 mg/dl. This emphasizes the importance of early diagnosis and treatment.

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期刊介绍: An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.
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