疑似病毒性脑炎供体器官恢复:一例报告与回顾

J. H. McDowell, B. L. Zingaro
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摘要

移植协调杂志1998年12月第8卷第4期入院时除腋窝有2 - 3厘米肿块外一切正常。此外,头部CT扫描正常。患者开始使用头孢曲松钠(罗舒芬),并加载苯妥英(苯妥英)。第2天进行腰椎穿刺(结果见表1)。患儿另外给予阿昔洛韦治疗,并治疗缺铁性贫血。大脑的核磁共振成像没有显示任何异常的发现。停用苯妥英,开始使用卡马西平(替格雷托尔)。第3天患儿再次癫痫发作,再次使用苯妥英汀。在儿童精神状态下降后,进行脑电图(EEG)显示边缘性正常活动。第4天复查CT正常;重复脑电图显示年龄背景节律缓慢,伴有广泛性小脑电功能障碍。在快速链球菌测试呈阳性后,Rocephin被停药。病人开始服用氨苄西林。当天晚些时候,患者再次癫痫发作,他接受了苯巴比妥治疗。在接下来的几个小时里,他的神经系统出现了明显的恶化。第5天,患者精神状态进一步下降,需插管及机械通气维持呼吸功能。患者被转介并转移到我们的机构器官恢复从捐赠者假定病毒性脑炎:一个病例报告和回顾
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Organ Recovery from a Donor with Presumed Viral Encephalitis: A Case Report and Review
Journal of Transplant Coordination, Vol. 8, Number 4, December 1998 tion upon admission was normal except for a 2to 3-cm axillary lump. In addition, the computed tomography (CT) scan of the head was normal. The patient was started on ceftriaxone sodium (Rocephin) and loaded with phenytoin (Dilantin). A lumbar puncture was performed on day 2 (results listed in Table 1). The child was additionally placed on acyclovir and treated for an iron deficiency anemia. A magnetic resonance imaging of the brain did not show any abnormal findings. Dilantin was discontinued and carbamazepine (Tegretol) was started. The child had another seizure on day 3 and Dilantin was recontinued. After a decline in the child’s mental status, an electroencephalograph (EEG) was performed showing borderline normal activity. A repeat CT scan on day 4 was normal; a repeat EEG revealed a slow background rhythm for age with generalized electrocerebellar dysfunction. Rocephin was discontinued after a rapid Streptococcus test was positive. The patient was then started on ampicillin. Later that day, the patient had another seizure for which he was treated with phenobarbital. He subsequently had significant neurologic deterioration over the next several hours. On day 5, the patient’s mental status declined further, and intubation and mechanical ventilation were required to support his respiratory function. The patient was referred and transferred to our institution Organ recovery from a donor with presumed viral encephalitis: a case report and review
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Financial incentives: alternatives to the altruistic model of organ donation. Xenotransplantation. Ethical challenges in infant heart transplantation: a clinical case presentation. No simple answers: ethical conflicts in pediatric heart transplantation. Ethics resources of US organ procurement organizations and transplant centers.
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