Marloe Prince, Charles J Glueck, Parth Shah, Ashwin Kumar, Michael Goldenberg, Matan Rothschild, Nasim Motayar, Vybhav Jetty, Kevin Lee, Ping Wang
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引用次数: 0
摘要
背景:在4年时间里,我们对因肺栓塞(PE)住院的患者进行了调查,评估了睾酮(TT)和雌激素治疗(ET)对发现有家族性血栓性疾病的患者预防PE的作用:从 2011 年到 2014 年,辛辛那提慈善医院共收治了 347 名因 PE 住院的患者。采用回顾性病历审查来确定在 PE 前接受 TT 或 ET 的患者;必要时进行前瞻性凝血研究:在因 PE 住院之前,154 名男性中有 8 人(5%)使用过 TT,193 名女性中有 24 人(12%)使用过 ET。从开始使用 TT 或 ET 到发生 PE 的中位月数,男性为 7 个月,女性为 18 个月。在有凝血指标的 6 名男性中,他们都有≥1 种血栓性疾病;在有凝血指标的 18 名女性中,16 人有≥1 种血栓性疾病。既往血栓病史对预测 PE 的敏感性较低,分别为 25%(2/8 名男性)和 4%(1/24 名女性):在因 PE 住院的 154 名男性中,有 8 人(5%)使用过 TT,在 193 名女性中,有 24 人(12%)使用过 ET。我们的数据表明, PE 是男性使用 TT 和女性使用 ET 的重要并发症,这在一定程度上反映了家族性和获得性血栓性疾病与使用外源性激素之间的相互作用。
Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia.
Background: In patients hospitalized over a 4 year period for pulmonary embolism (PE), we assessed relationships of testosterone (TT) and estrogen therapy (ET) anteceding PE in patients found to have familial-acquired thrombophilia.
Methods: From 2011 through 2014, 347 patients were hospitalized in Cincinnati Mercy Hospitals with PE. Retrospective chart review was used to identify patients receiving TT or ET before PE; coagulation studies were done prospectively if necessary.
Results: Preceding hospitalization for PE, 8 of 154 men (5 %) used TT, and 24 of 193 women (12 %) used ET. The median number of months from the initiation of TT or ET to development of PE was 7 months in men and 18 months in women. Of the 6 men having coagulation measures, all had ≥ 1 thrombophilia, and of the 18 women having measures of coagulation, 16 had ≥ 1 thrombophilia. The sensitivity of a previous history of thrombosis to predict PE was low, 25 % (2/8 men), 4 % (1/24 women).
Conclusions: Of 154 men hospitalized for PE, 8 (5 %) used TT, and of 193 women, 24 (12 %) used ET. Our data suggests that PE is an important complication of TT in men and ET in women, in part reflecting an interaction between familial and acquired thrombophilia and exogenous hormone use.
期刊介绍:
BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.