Wan-Kyu Lee, Hyeong-Jun Lim, S. Kim, H. Kimoto, S. Ohmomo, Y. Tashiro, H. Takebe
{"title":"乳酸乳球菌亚种的降胆固醇作用。乳酸菌生物变种二乙酰乳酸菌N7和乳酸菌亚球菌。SD大鼠乳酸杆菌527株","authors":"Wan-Kyu Lee, Hyeong-Jun Lim, S. Kim, H. Kimoto, S. Ohmomo, Y. Tashiro, H. Takebe","doi":"10.12938/BIFIDUS.24.11","DOIUrl":null,"url":null,"abstract":"The effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 (LACC-N7) and Lactococcus lactis subsp. lactis 527 (LACC-527) strains isolated from dairy products on serum cholesterol levels in the SD rats were investigated. The administration of LACC-N7 significantly decreased total serum cholesterol (p<0.001) and triglycerides (p<0.05) and increased HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks post-administration. LACC-527 had an effect on total serum cholesterol (p<0.05) and HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks and triglycerides (p<0.01) at 4 weeks post-administration. Enterococcus faecium (ENT-1) also significantly decreased total serum cholesterol (p<0.001), and increased the HDL-cholesterol ratio to total cholesterol (p<0.05). These results suggest that LACC-N7 and LACC-527 would be effective as probiotics for the prevention of hypercholesterolemia and fatty liver.","PeriodicalId":90114,"journal":{"name":"Bioscience and microflora","volume":"24 1","pages":"11-16"},"PeriodicalIF":0.0000,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.12938/BIFIDUS.24.11","citationCount":"16","resultStr":"{\"title\":\"Hypocholesterolemic Effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 and Lactococcus lactis subsp. lactis 527 Strains in SD Rats\",\"authors\":\"Wan-Kyu Lee, Hyeong-Jun Lim, S. Kim, H. Kimoto, S. Ohmomo, Y. Tashiro, H. Takebe\",\"doi\":\"10.12938/BIFIDUS.24.11\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 (LACC-N7) and Lactococcus lactis subsp. lactis 527 (LACC-527) strains isolated from dairy products on serum cholesterol levels in the SD rats were investigated. The administration of LACC-N7 significantly decreased total serum cholesterol (p<0.001) and triglycerides (p<0.05) and increased HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks post-administration. LACC-527 had an effect on total serum cholesterol (p<0.05) and HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks and triglycerides (p<0.01) at 4 weeks post-administration. Enterococcus faecium (ENT-1) also significantly decreased total serum cholesterol (p<0.001), and increased the HDL-cholesterol ratio to total cholesterol (p<0.05). These results suggest that LACC-N7 and LACC-527 would be effective as probiotics for the prevention of hypercholesterolemia and fatty liver.\",\"PeriodicalId\":90114,\"journal\":{\"name\":\"Bioscience and microflora\",\"volume\":\"24 1\",\"pages\":\"11-16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.12938/BIFIDUS.24.11\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioscience and microflora\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12938/BIFIDUS.24.11\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience and microflora","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12938/BIFIDUS.24.11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hypocholesterolemic Effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 and Lactococcus lactis subsp. lactis 527 Strains in SD Rats
The effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 (LACC-N7) and Lactococcus lactis subsp. lactis 527 (LACC-527) strains isolated from dairy products on serum cholesterol levels in the SD rats were investigated. The administration of LACC-N7 significantly decreased total serum cholesterol (p<0.001) and triglycerides (p<0.05) and increased HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks post-administration. LACC-527 had an effect on total serum cholesterol (p<0.05) and HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks and triglycerides (p<0.01) at 4 weeks post-administration. Enterococcus faecium (ENT-1) also significantly decreased total serum cholesterol (p<0.001), and increased the HDL-cholesterol ratio to total cholesterol (p<0.05). These results suggest that LACC-N7 and LACC-527 would be effective as probiotics for the prevention of hypercholesterolemia and fatty liver.
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