Siriraj医院妊娠期糖尿病妇女产后葡萄糖耐受不良的发生率

Pornprom Ittiamornlert, P. Sunsaneevithayakul, Dittakarn Borriboonhiransan
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摘要

目的:了解妊娠期糖尿病(GDM)妇女产后葡萄糖耐受不良的发生率及其相关因素。方法:纳入在Siriraj医院分娩的110名GDM妇女。在产后6-12周进行2小时75克葡萄糖耐量试验,以确定葡萄糖耐量不良(IGT)和2型糖尿病(T2DM)的发生率。收集人口统计数据、GDM风险和诊断数据以及分娩数据。估计葡萄糖耐受不良的发生率。葡萄糖耐受不良组之间进行比较,以确定可能的相关因素。结果:平均年龄为33.7±5.1岁,46%为无产。根据孕前体重指数,45.5%的人超重/肥胖,24.5%的人体重增加超过建议。多数为GDM A1(85.5%), 63.6%在妊娠20周前确诊。平均产后随访时间为6.2±0.9周。产后IGT和T2DM的发生率分别为35.5%和10%。在孕前BMI、妊娠期体重增加、体重保持和GDM严重程度方面,两组间没有发现差异。然而,产后T2DM妇女的HbA1c水平明显高于IGT和正常结果(分别为6.1±0.5%,5.6±0.4%和5.4±0.3%,p=0.001),显著增加了T2DM的发生几率(33.3%比53.4%,p=0.001)。结论:GDM孕妇中,产后葡萄糖耐受不良发生率为45.5%(其中IGT占35.5%,T2DM占10%)。HbA1c水平为6%显著增加产后2型糖尿病的发生几率。
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Incidence of postpartum glucose intolerance among women with gestational diabetes in Siriraj Hospital
Objectives: To determine the incidence of postpartum glucose intolerance among women with gestational diabetes (GDM) and its associated factors. Methods: A total of 110 GDM women who delivered at Siriraj Hospital were enrolled. A 2-hour 75-gram glucose tolerance test and were offered at 6-12 weeks postpartum to determine incidence of glucose intolerance, which include impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). Demographic data, GDM risks and diagnosis data, and delivery data were collected. Incidence of glucose intolerance was estimated. Comparison was made between glucose intolerance groups to determine possible associated factors. Results: Mean age was 33.7±5.1 years, and 46% were nulliparous. According to pre-pregnancy BMI, 45.5% were overweight/obese, and 24.5% gained weight greater than recommendation. Majority was GDM A1 (85.5%), and 63.6% were diagnosed before 20 weeks of gestation. Mean postpartum follow up time was at 6.2 ± 0.9 weeks. Incidence of postpartum IGT and T2DM were 35.5% and 10% respectively. No difference was found between groups in terms of pre-pregnancy BMI, gestational weight gain, weight retention, and severity of GDM. However, HbA1c level was significantly greater among women with postpartum T2DM than IGT and normal results (6.1±0.5%, 5.6±0.4%, and 5.4±0.3% respectively, p 6% significantly increased the chance of T2DM (33.3% vs. 53.4%, p=0.001). Conclusion: Among GDM pregnant women, incidence of postpartum glucose intolerance was 45.5% (35.5% IGT and 10% T2DM). HbA1c level of >6% significantly increased the chance of postpartum T2DM.
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来源期刊
Thai Journal of Obstetrics and Gynaecology
Thai Journal of Obstetrics and Gynaecology Medicine-Obstetrics and Gynecology
CiteScore
0.40
自引率
0.00%
发文量
3
审稿时长
24 weeks
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