具有传播模式和分布延迟的离散病毒感染模型

B. E. Boukari, K. Hattaf, J. E. Ghordaf
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引用次数: 0

摘要

这项工作的目的是提出和分析一个离散的病毒动力学模型,具有分布式延迟和两种传播模式,一种是病毒到细胞的感染,另一种是细胞到细胞的转移。在提出的模型中,第一个分布式延迟描述了受感染细胞产生新病毒粒子所需的时间,第二个分布式延迟描述了新产生的病毒粒子成熟和传染性所需的时间。此外,感染传播过程由两种模式的一般发生率函数建模。进一步证明了所提出的离散模型与相应的连续模型具有相同的动力学特性,如解的正性、有界性和全局行为,且对时间步长没有限制。通过数值模拟验证了本文的主要分析结果。
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A discrete viral infection model with both modes of transmission and distributed delays
: The aim of this work is to propose and analyse a discrete virus dynamics model with distributed delays and both modes of transmission, one by virus-to-cell infection and the other by cell-to-cell transfer. In the proposed model, the first distributed delays describes the time needed for infected cells to produce new virions, and the second portrays the time necessary for the newly produced virions to become mature and infectious. In addition, the infection transmission process is modelled by general incidence functions for both modes. Furthermore, we prove that the proposed discrete model has the same dynamics as the corresponding continuous model, such as positivity, boundedness and global behaviours of solutions with no restriction on the time step size. Moreover, numerical simulations are given to illustrate and confirm our main analytical results.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
16
期刊介绍: IJDSDE is a quarterly international journal that publishes original research papers of high quality in all areas related to dynamical systems and differential equations and their applications in biology, economics, engineering, physics, and other related areas of science. Manuscripts concerned with the development and application innovative mathematical tools and methods from dynamical systems and differential equations, are encouraged.
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