欧米伽-3软胶囊的崩解和破裂试验

IF 1 4区医学 Q4 PHARMACOLOGY & PHARMACY Dissolution Technologies Pub Date : 2021-01-01 DOI:10.14227/DT280121P6

N. Nyamweya, Teddy M. Mochama

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引用次数: 1

摘要

Omega-3脂肪酸软胶囊是一种流行的营养补充剂。以前在文献中报道的产品质量研究大多只涉及omega-3脂肪酸含量和化学稳定性方面的规格。本研究旨在通过崩解和破裂试验来表征omega-3软胶囊在水介质中的体外释放特性。四种明胶和一种非明胶(淀粉/卡拉胶)市售的欧米伽-3软胶囊产品以水和0.1盐酸为培养基进行了评估。一般来说，大多数产品在酸性介质中比在水中释放得更快。崩解与破裂试验次数有显著的统计学相关性。尽管产品间崩解和破裂试验时间差异很大，但在两种介质中，所有产品均在15分钟内破裂，30分钟内完全崩解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Disintegration and Rupture Testing of Omega-3 Soft Capsules

Omega-3 fatty acid soft capsules are a popular nutritional supplement. Previous product quality studies reported in the literature have mostly only addressed specifications for omega-3 fatty acid content and chemical stability aspects. This study aimed to characterize the in vitro release characteristics of omega-3 from soft capsules in aqueous media using disintegration and rupture tests. Four gelatin and one non-gelatin (starch/carrageen) commercially available omega-3 soft capsule products were evaluated using water and 0.1 N HCl as the media. In general, most products displayed faster release in the acidic medium compared to water. There was a statistically significant correlation between the disintegration and rupture test times. Although between-product disintegration and rupture test times varied considerably, all products ruptured within 15 minutes and completely disintegrated within 30 minutes in both media.

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来源期刊

Dissolution Technologies 医学-药学

CiteScore

1.20

自引率

33.30%

发文量

审稿时长

3 months

期刊介绍： Dissolution Technologies is a peer reviewed quarterly publication reporting ongoing, useful information on dissolution testing of pharmaceuticals. It provides an international forum for dissolution analysts to receive and exchange information on various dissolution topics. Dissolution Technologies welcomes submissions related to dissolution, in vitro release, and disintegration testing. These topics should be the major focus of the article. Do not submit articles where the focus is formulation development with dissolution testing as one of many tests.