ZGDHu-1纳米颗粒的制备与表征

IF 1 4区医学 Q4 PHARMACOLOGY & PHARMACY Dissolution Technologies Pub Date : 2021-01-01 DOI:10.14227/dt280321p40

Lei Shi, Yong-li Liu, Kunlin Wu, Ruiz Si

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引用次数: 0

摘要

本研究的目的是建立ZGDHu-1纳米颗粒的制备工艺，并研究其物理化学性质。采用高压均质法制备纳米颗粒。以天然磷脂和大豆油为药物载体，Cremophor EL为表面活性剂。所制得的纳米颗粒呈球形，平均±SD粒径为106.8±15.9 nm, PDI为0.136±0.011,zeta电位为-63.97±3.57 mV，包封率为86.95%，24 h体外累积释放率为84.67%。制备工艺简单，重现性好。纳米颗粒具有良好的物理化学性质，并通过增加溶解度来改善体外释放。本研究为ZGDHu-1纳米颗粒制剂的开发提供了改善其体外释放的方法。

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Preparation and Characterization of ZGDHu-1 Nanoparticles

The purpose of this study was to establish the preparation process of ZGDHu-1 nanoparticles and to study its physicochemical properties. The nanoparticles were prepared using a high-pressure homogenization method. Natural phospholipid and soybean oil were used as drug carriers, and Cremophor EL was used as surfactant. The resulting nanoparticles had a spherical shape, with a mean ± SD particle size of 106.8 ± 15.9 nm, polydispersity index (PDI) of 0.136 ± 0.011, zeta potential of -63.97 ± 3.57 mV, encapsulation efficiency of 86.95%, and in vitro cumulative release rate of 84.67% in 24 hours. The nanoparticle preparation process was simple and reproducible. The nanoparticles had good physicochemical properties and in vitro release was improved by increasing solubility. This study provides a method for improving in vitro release for development of ZGDHu-1 nanoparticle formulations.

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来源期刊

Dissolution Technologies 医学-药学

CiteScore

1.20

自引率

33.30%

发文量

审稿时长

3 months

期刊介绍： Dissolution Technologies is a peer reviewed quarterly publication reporting ongoing, useful information on dissolution testing of pharmaceuticals. It provides an international forum for dissolution analysts to receive and exchange information on various dissolution topics. Dissolution Technologies welcomes submissions related to dissolution, in vitro release, and disintegration testing. These topics should be the major focus of the article. Do not submit articles where the focus is formulation development with dissolution testing as one of many tests.