半马酸比索洛尔经皮给药凝胶的研制及评价

IF 1 4区医学 Q4 PHARMACOLOGY & PHARMACY Dissolution Technologies Pub Date : 2022-01-01 DOI:10.14227/dt290522p38

R. Gul, Y. Khan, Tajala Aman

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引用次数: 0

摘要

本研究以卡波尔934P为原料，以胸腺油和橄榄油为促进剂，制备半马来酸比索洛尔凝胶，并对其进行评价。胸腺油和橄榄油作为渗透促进剂。将乳液配方添加到基础凝胶中。对该乳液进行了物理特性、稳定性、皮肤刺激性和药物释放的表征。与其他制剂相比，配方F1和F5的体外释放效果最佳。含有卡波醇934P和胸腺油或橄榄油增强剂的半马来酸比索洛尔凝胶可以进一步开发用于局部给药系统。

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Formulation and Evaluation of Bisoprolol Hemifumarate Emulgel for Transdermal Drug Delivery

The aim of this study was to formulate and evaluate bisoprolol hemifumarate emulgel using carbopol 934P with the enhancers, thymus oil and olive oil. Thymus oil and olive oil were used as permeation enhancers. The emulsion formulations were added to a base gel. The emulgel was characterized for physical characteristics, stability, skin irritation, and drug release. Formulations F1 and F5 indicated the best in-vitro drug release when compared with other preparations. Bisoprolol hemifumarate emulgel containing carbopol 934P and thymus oil or olive oil enhancers could be further developed for a topical drug delivery system.

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来源期刊

Dissolution Technologies 医学-药学

CiteScore

1.20

自引率

33.30%

发文量

审稿时长

3 months

期刊介绍： Dissolution Technologies is a peer reviewed quarterly publication reporting ongoing, useful information on dissolution testing of pharmaceuticals. It provides an international forum for dissolution analysts to receive and exchange information on various dissolution topics. Dissolution Technologies welcomes submissions related to dissolution, in vitro release, and disintegration testing. These topics should be the major focus of the article. Do not submit articles where the focus is formulation development with dissolution testing as one of many tests.