血管神经病理对晚年认知的影响:来自SMART项目的结果。

IF 8.5 3区 医学 Q1 CLINICAL NEUROLOGY Jpad-Journal of Prevention of Alzheimers Disease Pub Date : 2016-06-01 DOI:10.14283/JPAD.2016.95
R. Kryscio, E. Abner, Peter T. Nelson, David A. Bennett, J. Schneider, Lei Yu, L. Hemmy, K. Lim, Kamal Masaki, N. Cairns, C. Xiong, R. Woltjer, H. Dodge, S. Tyas, D. Fardo, W. Lou, L. Wan, F. Schmitt
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引用次数: 16

摘要

背景:脑血管病理可能导致一些濒临死亡的老年人认知能力下降。鉴于老年混合神经病变的证据,预防或减少晚年脑血管负担可能是有益的。目的探讨脑血管病理指标与认知轨迹的相关性。SETTINGObservational研究。研究人员从六个进行纵向研究的中心收集了2274名平均年龄为89.3岁的人进行尸检,其中82%的人在过去六年内至少进行了两次认知评估。测量对于每个认知领域:即时和延迟记忆,语言和命名,三个轨迹被检查:良好,中等和差的认知。在调整人口统计学、APOE和阿尔茨海默病神经病理学后,参与者属于每种轨迹的概率与脑血管病理学测量相关。结果大比例的队列(72-94%)在四个检查领域的认知良好或中等。小动脉硬化和腔隙性梗死的存在使语言认知轨迹较差的几率比良好轨迹增加了一倍。腔隙性梗死的存在增加了即时和延迟回忆的中间或不良轨迹的几率,而大动脉梗死的存在增加了所有四个认知领域的不良轨迹的几率。微梗死和脑淀粉样血管病对轨迹影响不大。结论脑血管病理指标对晚年认知的影响存在差异。
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The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project.
BACKGROUND Cerebral vascular pathology may contribute to cognitive decline experienced by some elderly near death. Given evidence for mixed neuropathologies in advanced age, preventing or reducing cerebrovascular burden in late life may be beneficial. OBJECTIVE To correlate measures of cerebral vascular pathology with cognitive trajectories. SETTING Observational study. PARTICIPANTS A cohort of 2,274 individuals who came to autopsy at a mean age of 89.3 years and 82 percent of whom had at least two cognitive assessments within the last six years of life was compiled from six centers conducting longitudinal studies. MEASUREMENTS For each cognitive domain: immediate and delayed memory, language, and naming, three trajectories were examined: good, intermediate, and poor cognition. The probability of a participant belonging to each trajectory was associated with measures of cerebral vascular pathology after adjustment for demographics, APOE, and Alzheimer neuropathology. RESULTS A large proportion of the cohort (72-94%) experienced good or intermediate cognition in the four domains examined. The presence of arteriolosclerosis and the presence of lacunar infarcts doubled the odds of belonging to the poor cognitive trajectory for language when compared to the good trajectory. The presence of lacunar infarcts increased the odds of an intermediate or poor trajectory for immediate and delayed recall while the presence of large artery infarcts increased the odds of poor trajectories for all four cognitive domains examined. Microinfarcts and cerebral amyloid angiopathy had little effect on the trajectories. CONCLUSION Indicators of cerebral vascular pathology act differently on late life cognition.
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期刊介绍: The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes. JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.
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