R. Kryscio, E. Abner, Peter T. Nelson, David A. Bennett, J. Schneider, Lei Yu, L. Hemmy, K. Lim, Kamal Masaki, N. Cairns, C. Xiong, R. Woltjer, H. Dodge, S. Tyas, D. Fardo, W. Lou, L. Wan, F. Schmitt
{"title":"血管神经病理对晚年认知的影响:来自SMART项目的结果。","authors":"R. Kryscio, E. Abner, Peter T. Nelson, David A. Bennett, J. Schneider, Lei Yu, L. Hemmy, K. Lim, Kamal Masaki, N. Cairns, C. Xiong, R. Woltjer, H. Dodge, S. Tyas, D. Fardo, W. Lou, L. Wan, F. Schmitt","doi":"10.14283/JPAD.2016.95","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nCerebral vascular pathology may contribute to cognitive decline experienced by some elderly near death. Given evidence for mixed neuropathologies in advanced age, preventing or reducing cerebrovascular burden in late life may be beneficial.\n\n\nOBJECTIVE\nTo correlate measures of cerebral vascular pathology with cognitive trajectories.\n\n\nSETTING\nObservational study.\n\n\nPARTICIPANTS\nA cohort of 2,274 individuals who came to autopsy at a mean age of 89.3 years and 82 percent of whom had at least two cognitive assessments within the last six years of life was compiled from six centers conducting longitudinal studies.\n\n\nMEASUREMENTS\nFor each cognitive domain: immediate and delayed memory, language, and naming, three trajectories were examined: good, intermediate, and poor cognition. The probability of a participant belonging to each trajectory was associated with measures of cerebral vascular pathology after adjustment for demographics, APOE, and Alzheimer neuropathology.\n\n\nRESULTS\nA large proportion of the cohort (72-94%) experienced good or intermediate cognition in the four domains examined. The presence of arteriolosclerosis and the presence of lacunar infarcts doubled the odds of belonging to the poor cognitive trajectory for language when compared to the good trajectory. The presence of lacunar infarcts increased the odds of an intermediate or poor trajectory for immediate and delayed recall while the presence of large artery infarcts increased the odds of poor trajectories for all four cognitive domains examined. Microinfarcts and cerebral amyloid angiopathy had little effect on the trajectories.\n\n\nCONCLUSION\nIndicators of cerebral vascular pathology act differently on late life cognition.","PeriodicalId":48606,"journal":{"name":"Jpad-Journal of Prevention of Alzheimers Disease","volume":null,"pages":null},"PeriodicalIF":8.5000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":"{\"title\":\"The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project.\",\"authors\":\"R. Kryscio, E. Abner, Peter T. Nelson, David A. Bennett, J. Schneider, Lei Yu, L. Hemmy, K. Lim, Kamal Masaki, N. Cairns, C. Xiong, R. Woltjer, H. Dodge, S. Tyas, D. Fardo, W. Lou, L. Wan, F. Schmitt\",\"doi\":\"10.14283/JPAD.2016.95\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nCerebral vascular pathology may contribute to cognitive decline experienced by some elderly near death. Given evidence for mixed neuropathologies in advanced age, preventing or reducing cerebrovascular burden in late life may be beneficial.\\n\\n\\nOBJECTIVE\\nTo correlate measures of cerebral vascular pathology with cognitive trajectories.\\n\\n\\nSETTING\\nObservational study.\\n\\n\\nPARTICIPANTS\\nA cohort of 2,274 individuals who came to autopsy at a mean age of 89.3 years and 82 percent of whom had at least two cognitive assessments within the last six years of life was compiled from six centers conducting longitudinal studies.\\n\\n\\nMEASUREMENTS\\nFor each cognitive domain: immediate and delayed memory, language, and naming, three trajectories were examined: good, intermediate, and poor cognition. The probability of a participant belonging to each trajectory was associated with measures of cerebral vascular pathology after adjustment for demographics, APOE, and Alzheimer neuropathology.\\n\\n\\nRESULTS\\nA large proportion of the cohort (72-94%) experienced good or intermediate cognition in the four domains examined. The presence of arteriolosclerosis and the presence of lacunar infarcts doubled the odds of belonging to the poor cognitive trajectory for language when compared to the good trajectory. The presence of lacunar infarcts increased the odds of an intermediate or poor trajectory for immediate and delayed recall while the presence of large artery infarcts increased the odds of poor trajectories for all four cognitive domains examined. Microinfarcts and cerebral amyloid angiopathy had little effect on the trajectories.\\n\\n\\nCONCLUSION\\nIndicators of cerebral vascular pathology act differently on late life cognition.\",\"PeriodicalId\":48606,\"journal\":{\"name\":\"Jpad-Journal of Prevention of Alzheimers Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.5000,\"publicationDate\":\"2016-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jpad-Journal of Prevention of Alzheimers Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14283/JPAD.2016.95\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jpad-Journal of Prevention of Alzheimers Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14283/JPAD.2016.95","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project.
BACKGROUND
Cerebral vascular pathology may contribute to cognitive decline experienced by some elderly near death. Given evidence for mixed neuropathologies in advanced age, preventing or reducing cerebrovascular burden in late life may be beneficial.
OBJECTIVE
To correlate measures of cerebral vascular pathology with cognitive trajectories.
SETTING
Observational study.
PARTICIPANTS
A cohort of 2,274 individuals who came to autopsy at a mean age of 89.3 years and 82 percent of whom had at least two cognitive assessments within the last six years of life was compiled from six centers conducting longitudinal studies.
MEASUREMENTS
For each cognitive domain: immediate and delayed memory, language, and naming, three trajectories were examined: good, intermediate, and poor cognition. The probability of a participant belonging to each trajectory was associated with measures of cerebral vascular pathology after adjustment for demographics, APOE, and Alzheimer neuropathology.
RESULTS
A large proportion of the cohort (72-94%) experienced good or intermediate cognition in the four domains examined. The presence of arteriolosclerosis and the presence of lacunar infarcts doubled the odds of belonging to the poor cognitive trajectory for language when compared to the good trajectory. The presence of lacunar infarcts increased the odds of an intermediate or poor trajectory for immediate and delayed recall while the presence of large artery infarcts increased the odds of poor trajectories for all four cognitive domains examined. Microinfarcts and cerebral amyloid angiopathy had little effect on the trajectories.
CONCLUSION
Indicators of cerebral vascular pathology act differently on late life cognition.
期刊介绍:
The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.
JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.