{"title":"嗜铬细胞瘤——一种特殊的内分泌肿瘤","authors":"Pál Perge, Péter Igaz","doi":"10.1556/2065.184.2023.8.5","DOIUrl":null,"url":null,"abstract":"Pheochromocytoma is a rare neuroendocrine tumour, which has the highest rate of heritability among all human tumours. It originates predominantly from the adrenal medulla, however approximately 20% of all cases are located extra-adrenally (so called paraganglioma). The catecholamine hormones released from the tumour can lead to diverse clinical manifestations. Pheochromocytoma is a peculiar endocrine tumour characterized by three major aspects. Its high heritability is related to the observation that germline mutations can be detected in about 40% of patients affected by pheochromocytoma. Moreover, somatic mutations can be identified in a big proportion of non-hereditary, sporadic tumours. To date, more than 20 genes","PeriodicalId":86120,"journal":{"name":"Magyar tudomany : [a Magyar Tudomanyos Akademia Ertesitoje]","volume":"19 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A feokromocitóma – egy különleges endokrin daganat • Pheochromocytoma–A Peculiar Endocrine Tumour\",\"authors\":\"Pál Perge, Péter Igaz\",\"doi\":\"10.1556/2065.184.2023.8.5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pheochromocytoma is a rare neuroendocrine tumour, which has the highest rate of heritability among all human tumours. It originates predominantly from the adrenal medulla, however approximately 20% of all cases are located extra-adrenally (so called paraganglioma). The catecholamine hormones released from the tumour can lead to diverse clinical manifestations. Pheochromocytoma is a peculiar endocrine tumour characterized by three major aspects. Its high heritability is related to the observation that germline mutations can be detected in about 40% of patients affected by pheochromocytoma. Moreover, somatic mutations can be identified in a big proportion of non-hereditary, sporadic tumours. To date, more than 20 genes\",\"PeriodicalId\":86120,\"journal\":{\"name\":\"Magyar tudomany : [a Magyar Tudomanyos Akademia Ertesitoje]\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Magyar tudomany : [a Magyar Tudomanyos Akademia Ertesitoje]\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1556/2065.184.2023.8.5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magyar tudomany : [a Magyar Tudomanyos Akademia Ertesitoje]","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1556/2065.184.2023.8.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A feokromocitóma – egy különleges endokrin daganat • Pheochromocytoma–A Peculiar Endocrine Tumour
Pheochromocytoma is a rare neuroendocrine tumour, which has the highest rate of heritability among all human tumours. It originates predominantly from the adrenal medulla, however approximately 20% of all cases are located extra-adrenally (so called paraganglioma). The catecholamine hormones released from the tumour can lead to diverse clinical manifestations. Pheochromocytoma is a peculiar endocrine tumour characterized by three major aspects. Its high heritability is related to the observation that germline mutations can be detected in about 40% of patients affected by pheochromocytoma. Moreover, somatic mutations can be identified in a big proportion of non-hereditary, sporadic tumours. To date, more than 20 genes