{"title":"氧化衍生化分光光度法测定药物制剂中哌嗪的含量","authors":"M. Blazheyevskiy, V. Moroz","doi":"10.17721/fujcv7i2p52-60","DOIUrl":null,"url":null,"abstract":"A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2019-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A new oxidative derivatization method for spectrophotometric determination of Periciazine in pharmaceutical preparations\",\"authors\":\"M. Blazheyevskiy, V. Moroz\",\"doi\":\"10.17721/fujcv7i2p52-60\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ\",\"PeriodicalId\":42056,\"journal\":{\"name\":\"French-Ukrainian Journal of Chemistry\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2019-12-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"French-Ukrainian Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17721/fujcv7i2p52-60\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"French-Ukrainian Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17721/fujcv7i2p52-60","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 1
摘要
提出了一种新的过氧化物酸氧化衍生法间接光度法测定哌嗪的方法。提出了一种以过氧单硫酸氢钾为衍生剂，在λ max =362 nm处制得吸收性Periciazine亚砜。该反应产物成功地用于分光光度法测定哌嗪。紫外分光光度法测定哌嗪亚砜是一种简便、选择性好的方法。定量限(LOQ=10S)为2.8µg·mL-1。常用赋形剂对吩噻嗪类药物的测定无干扰。该方法与官方方法的分析结果吻合较好。Rsd = 1.76% (δ
A new oxidative derivatization method for spectrophotometric determination of Periciazine in pharmaceutical preparations
A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ
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