Contact phase of blood coagulation and thrombosis and hypertension: The conundrum has to be clarified

There is another peculiar observation with regard to PK deficiency: the large majority of thrombotic events concern the arterial system. As the matter of fact, the only venous thrombosis occurred in two sisters who, besides PK deficiency, showed also severe obesity [13]. On the contrary, these is no similar striking difference in FXII deficiency. It seems, in other words, that arterial thrombosis is probably associated with PK deficiency. This action seems mediated by the hypertension which has been frequently found in patients with PK deficiency [6].