Karivachery V. Sudheesh, Prasad S. Jayaram, Dr. Animesh Samanta, Dr. Kochan S. Bejoymohandas, Dr. Ramapurath S. Jayasree, Prof.?Dr. Ayyappanpillai Ajayaghosh
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Frontispiece: A Cyclometalated IrIII Complex as a Lysosome-Targeted Photodynamic Therapeutic Agent for Integrated Imaging and Therapy in Cancer Cells
Organelle-targeted photosensitizers with luminescence properties are potential theranostic agents for simultaneous imaging and photodynamic therapy. Described herein is a cyclometalated IrIII complex, Ir-Bp-Ly, that exhibits high triplet quantum yield and singlet-oxygen-generation efficiency. The close-proximity energy levels between triplet energy states of Ir-Bp-Ly and molecular oxygen favors efficient singlet oxygen and reactive oxygen species (ROS) generation. The good lysosomal specificity of Ir-Bp-Ly leads to its increased efficacy as a photodynamic therapeutic and imaging agent. More information can be found in the Full Paper by A. Ajayaghosh et al. on page 10999 ff.
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