{"title":"抗抑郁药物(丙咪嗪和氟西汀)对雌性Wistar大鼠卵巢基因转录的影响","authors":"Oyedeji K.O, Uwadiale D.","doi":"10.18006/2023.11(3).593.597","DOIUrl":null,"url":null,"abstract":"This study was designed to investigate ovarian gene transcriptional responses to selected antidepressant drugs (imipramine and fluoxetine) in female rats. Fifteen female rats (120 – 140 g) were used for this study. Imipramine (0.71 mg/kg) and fluoxetine (0.57 mg/kg) were given orally for 50 days. The method of RT-PCR was employed to investigate the expressions of FSH-R, p53 and Bcl-2 genes. Graphics were generated as mean +/- SEM using GraphPad Prism version 8.0. Results of the study revealed that the FSH-R, p53 and Bcl-2 expressions were significantly (p<0.05) up-regulated in the imipramine-treated rats relative to their controls. Conclusively, it can be suggested that imipramine induced follicular growth and apoptosis in female Wistar rats.","PeriodicalId":15766,"journal":{"name":"Journal of Experimental Biology and Agricultural Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ovarian Gene Transcriptional Responses To Antidepressant Drugs (Imipramine And Fluoxetine) In Female Wistar Rats\",\"authors\":\"Oyedeji K.O, Uwadiale D.\",\"doi\":\"10.18006/2023.11(3).593.597\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study was designed to investigate ovarian gene transcriptional responses to selected antidepressant drugs (imipramine and fluoxetine) in female rats. Fifteen female rats (120 – 140 g) were used for this study. Imipramine (0.71 mg/kg) and fluoxetine (0.57 mg/kg) were given orally for 50 days. The method of RT-PCR was employed to investigate the expressions of FSH-R, p53 and Bcl-2 genes. Graphics were generated as mean +/- SEM using GraphPad Prism version 8.0. Results of the study revealed that the FSH-R, p53 and Bcl-2 expressions were significantly (p<0.05) up-regulated in the imipramine-treated rats relative to their controls. Conclusively, it can be suggested that imipramine induced follicular growth and apoptosis in female Wistar rats.\",\"PeriodicalId\":15766,\"journal\":{\"name\":\"Journal of Experimental Biology and Agricultural Sciences\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Experimental Biology and Agricultural Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18006/2023.11(3).593.597\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Veterinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental Biology and Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18006/2023.11(3).593.597","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Veterinary","Score":null,"Total":0}
Ovarian Gene Transcriptional Responses To Antidepressant Drugs (Imipramine And Fluoxetine) In Female Wistar Rats
This study was designed to investigate ovarian gene transcriptional responses to selected antidepressant drugs (imipramine and fluoxetine) in female rats. Fifteen female rats (120 – 140 g) were used for this study. Imipramine (0.71 mg/kg) and fluoxetine (0.57 mg/kg) were given orally for 50 days. The method of RT-PCR was employed to investigate the expressions of FSH-R, p53 and Bcl-2 genes. Graphics were generated as mean +/- SEM using GraphPad Prism version 8.0. Results of the study revealed that the FSH-R, p53 and Bcl-2 expressions were significantly (p<0.05) up-regulated in the imipramine-treated rats relative to their controls. Conclusively, it can be suggested that imipramine induced follicular growth and apoptosis in female Wistar rats.
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