{"title":"儿童间变性大细胞淋巴瘤a综述","authors":"Soumitra Tole, Laura Wheaton, S. Alexander","doi":"10.17925/OHR.2018.14.1.21","DOIUrl":null,"url":null,"abstract":"Anaplastic large cell lymphoma (ALCL) is the most common pediatric peripheral T-cell lymphoma, accounting for 10–15% of pediatric non-Hodgkin lymphoma. Patients with pediatric ALCL commonly present at an advanced stage of disease and, unlike adult ALCL, the majority of pediatric cases demonstrate overexpression of anaplastic lymphoma kinase (ALK). Despite a range of treatment strategies, event-free survival has remained stagnant at 65–75%. The role of novel targeted therapies such as ALK inhibitors and anti-CD30 antibody drug conjugates are actively being studied in both the newly diagnosed and relapse setting. This review article will cover the pathology, clinical presentation, and prognostic factors for pediatric ALCL, and will focus on a discussion of the therapeutic strategies for this disease.","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"14 1","pages":"21"},"PeriodicalIF":0.7000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Pediatric Anaplastic Large Cell Lymphoma—A Review\",\"authors\":\"Soumitra Tole, Laura Wheaton, S. Alexander\",\"doi\":\"10.17925/OHR.2018.14.1.21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Anaplastic large cell lymphoma (ALCL) is the most common pediatric peripheral T-cell lymphoma, accounting for 10–15% of pediatric non-Hodgkin lymphoma. Patients with pediatric ALCL commonly present at an advanced stage of disease and, unlike adult ALCL, the majority of pediatric cases demonstrate overexpression of anaplastic lymphoma kinase (ALK). Despite a range of treatment strategies, event-free survival has remained stagnant at 65–75%. The role of novel targeted therapies such as ALK inhibitors and anti-CD30 antibody drug conjugates are actively being studied in both the newly diagnosed and relapse setting. This review article will cover the pathology, clinical presentation, and prognostic factors for pediatric ALCL, and will focus on a discussion of the therapeutic strategies for this disease.\",\"PeriodicalId\":44122,\"journal\":{\"name\":\"Oral History Review\",\"volume\":\"14 1\",\"pages\":\"21\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral History Review\",\"FirstCategoryId\":\"98\",\"ListUrlMain\":\"https://doi.org/10.17925/OHR.2018.14.1.21\",\"RegionNum\":1,\"RegionCategory\":\"历史学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HISTORY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral History Review","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.17925/OHR.2018.14.1.21","RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HISTORY","Score":null,"Total":0}
Anaplastic large cell lymphoma (ALCL) is the most common pediatric peripheral T-cell lymphoma, accounting for 10–15% of pediatric non-Hodgkin lymphoma. Patients with pediatric ALCL commonly present at an advanced stage of disease and, unlike adult ALCL, the majority of pediatric cases demonstrate overexpression of anaplastic lymphoma kinase (ALK). Despite a range of treatment strategies, event-free survival has remained stagnant at 65–75%. The role of novel targeted therapies such as ALK inhibitors and anti-CD30 antibody drug conjugates are actively being studied in both the newly diagnosed and relapse setting. This review article will cover the pathology, clinical presentation, and prognostic factors for pediatric ALCL, and will focus on a discussion of the therapeutic strategies for this disease.
期刊介绍：
The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.
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