{"title":"希望的曙光- BRAF v600e突变的转移性结直肠癌患者克服治疗耐药的新策略","authors":"S. Armstrong, Rita Malley, B. Weinberg","doi":"10.17925/ohr.2020.16.1.31","DOIUrl":null,"url":null,"abstract":"BRAF V600E-mutated metastatic colorectal cancer is notoriously difficult to treat due to an aggressive tumor biology and resistance to chemotherapy. Single-agent BRAF inhibition has proven ineffective in this patient population. Approaches combining BRAF with epidermal growth factor receptor and mitogen-activated extracellular signal-regulated kinase inhibition are effective in overcoming resistance to BRAF monotherapy, and this treatment combination provides a superior overall survival benefit compared with irinotecan-based chemotherapy. Encorafenib plus cetuximab is now a US Food and Drug Administration-approved treatment option for patients with BRAF V600E-mutated metastatic colorectal cancer after prior therapy. Ongoing clinical trials using immunotherapy and other targeted agents aim to further improve on these outcomes. We highlight the epidemiology and mutational landscape of BRAF-mutated colorectal cancer, as well as novel treatment options for patients with this subtype of metastatic colorectal cancer.","PeriodicalId":44122,"journal":{"name":"Oral History Review","volume":"16 1","pages":"31"},"PeriodicalIF":0.7000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glimmers of Hope—New Strategies for Overcoming Treatment Resistance in Patients with BRAF V600E-mutated Metastatic Colorectal Cancer\",\"authors\":\"S. Armstrong, Rita Malley, B. Weinberg\",\"doi\":\"10.17925/ohr.2020.16.1.31\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BRAF V600E-mutated metastatic colorectal cancer is notoriously difficult to treat due to an aggressive tumor biology and resistance to chemotherapy. Single-agent BRAF inhibition has proven ineffective in this patient population. Approaches combining BRAF with epidermal growth factor receptor and mitogen-activated extracellular signal-regulated kinase inhibition are effective in overcoming resistance to BRAF monotherapy, and this treatment combination provides a superior overall survival benefit compared with irinotecan-based chemotherapy. Encorafenib plus cetuximab is now a US Food and Drug Administration-approved treatment option for patients with BRAF V600E-mutated metastatic colorectal cancer after prior therapy. Ongoing clinical trials using immunotherapy and other targeted agents aim to further improve on these outcomes. We highlight the epidemiology and mutational landscape of BRAF-mutated colorectal cancer, as well as novel treatment options for patients with this subtype of metastatic colorectal cancer.\",\"PeriodicalId\":44122,\"journal\":{\"name\":\"Oral History Review\",\"volume\":\"16 1\",\"pages\":\"31\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral History Review\",\"FirstCategoryId\":\"98\",\"ListUrlMain\":\"https://doi.org/10.17925/ohr.2020.16.1.31\",\"RegionNum\":1,\"RegionCategory\":\"历史学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HISTORY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral History Review","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.17925/ohr.2020.16.1.31","RegionNum":1,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HISTORY","Score":null,"Total":0}
Glimmers of Hope—New Strategies for Overcoming Treatment Resistance in Patients with BRAF V600E-mutated Metastatic Colorectal Cancer
BRAF V600E-mutated metastatic colorectal cancer is notoriously difficult to treat due to an aggressive tumor biology and resistance to chemotherapy. Single-agent BRAF inhibition has proven ineffective in this patient population. Approaches combining BRAF with epidermal growth factor receptor and mitogen-activated extracellular signal-regulated kinase inhibition are effective in overcoming resistance to BRAF monotherapy, and this treatment combination provides a superior overall survival benefit compared with irinotecan-based chemotherapy. Encorafenib plus cetuximab is now a US Food and Drug Administration-approved treatment option for patients with BRAF V600E-mutated metastatic colorectal cancer after prior therapy. Ongoing clinical trials using immunotherapy and other targeted agents aim to further improve on these outcomes. We highlight the epidemiology and mutational landscape of BRAF-mutated colorectal cancer, as well as novel treatment options for patients with this subtype of metastatic colorectal cancer.
期刊介绍：
The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.
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