{"title":"疟疾感染红细胞中蛋白激酶调节的内校正阴离子和有机渗透通道","authors":"G. Bouyer, Serge L. Y. Thomas, S. Egée","doi":"10.2174/1874196701104010010","DOIUrl":null,"url":null,"abstract":"The intraerythrocytic amplification of the malaria parasite Plasmodium falciparum induces new pathways of solute permeability in the host cell's membrane. These pathways play a pivotal role in parasite development by supplying the parasite with nutrients, disposing of the parasite's metabolic waste and organic osmolytes, and adapting the host's electrolyte composition to the parasite's needs. During the last ten years, electrophysiological investigations strongly supported earlier evidence obtained by transport and pharmacological studies that this new permeability pathway, which is induced by the parasite in the host cell membrane, is constituted by anion-selective channels. This review surveys the evidences acquired using the patch-clamp technique and discuss the hypothesis that protein kinase A is an effector of the signalling pathway leading to the activation of endogenous channels upon infection.","PeriodicalId":38956,"journal":{"name":"Open Bioinformatics Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2011-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Protein Kinase-Regulated Inwardly Rectifying Anion and Organic Osmolyte Channels in Malaria-Infected Erythrocytes\",\"authors\":\"G. Bouyer, Serge L. Y. Thomas, S. Egée\",\"doi\":\"10.2174/1874196701104010010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The intraerythrocytic amplification of the malaria parasite Plasmodium falciparum induces new pathways of solute permeability in the host cell's membrane. These pathways play a pivotal role in parasite development by supplying the parasite with nutrients, disposing of the parasite's metabolic waste and organic osmolytes, and adapting the host's electrolyte composition to the parasite's needs. During the last ten years, electrophysiological investigations strongly supported earlier evidence obtained by transport and pharmacological studies that this new permeability pathway, which is induced by the parasite in the host cell membrane, is constituted by anion-selective channels. This review surveys the evidences acquired using the patch-clamp technique and discuss the hypothesis that protein kinase A is an effector of the signalling pathway leading to the activation of endogenous channels upon infection.\",\"PeriodicalId\":38956,\"journal\":{\"name\":\"Open Bioinformatics Journal\",\"volume\":\"4 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Bioinformatics Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874196701104010010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Computer Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Bioinformatics Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874196701104010010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Computer Science","Score":null,"Total":0}
Protein Kinase-Regulated Inwardly Rectifying Anion and Organic Osmolyte Channels in Malaria-Infected Erythrocytes
The intraerythrocytic amplification of the malaria parasite Plasmodium falciparum induces new pathways of solute permeability in the host cell's membrane. These pathways play a pivotal role in parasite development by supplying the parasite with nutrients, disposing of the parasite's metabolic waste and organic osmolytes, and adapting the host's electrolyte composition to the parasite's needs. During the last ten years, electrophysiological investigations strongly supported earlier evidence obtained by transport and pharmacological studies that this new permeability pathway, which is induced by the parasite in the host cell membrane, is constituted by anion-selective channels. This review surveys the evidences acquired using the patch-clamp technique and discuss the hypothesis that protein kinase A is an effector of the signalling pathway leading to the activation of endogenous channels upon infection.
期刊介绍:
The Open Bioinformatics Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters, clinical trial studies and guest edited single topic issues in all areas of bioinformatics and computational biology. The coverage includes biomedicine, focusing on large data acquisition, analysis and curation, computational and statistical methods for the modeling and analysis of biological data, and descriptions of new algorithms and databases. The Open Bioinformatics Journal, a peer reviewed journal, is an important and reliable source of current information on the developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.