PHD2:从缺氧调节到疾病进展

A. Meneses, B. Wielockx
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引用次数: 54

摘要

氧是生命发展和维持所必需的主要分子之一。因此,大多数生物体的功能需要对缺氧作出充分的反应,并依赖于缺氧诱导因子(HIF)途径的激活。HIF脯氨酸羟化酶结构域-2 (PHD2)长期以来被认为是这种反应的主要调节因子,控制着从细胞死亡到增殖的无数结果。然而,这种酶与更多的途径相关,使得这种蛋白质在不同病理下的作用非常复杂。虽然保护作用似乎存在于生理条件,如红细胞生成;在癌症等疾病中,情况更为复杂。由于该酶及其最近的家族成员的调控目前被认为是多种疾病的可能治疗方法,因此了解该蛋白的不同特定作用是必不可少的。
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PHD2: from hypoxia regulation to disease progression
Oxygen represents one of the major molecules required for the development and maintenance of life. An adequate response to hypoxia is therefore required for the functioning of the majority of living organisms and relies on the activation of the hypoxia-inducible factor (HIF) pathway. HIF prolyl hydroxylase domain-2 (PHD2) has long been recognized as the major regulator of this response, controlling a myriad of outcomes that range from cell death to proliferation. However, this enzyme has been associated with more pathways, making the role of this protein remarkably complex under distinct pathologies. While a protective role seems to exist in physiological conditions such as erythropoiesis; the picture is more complex during pathologies such as cancer. Since the regulation of this enzyme and its closest family members is currently considered as a possible therapy for various diseases, understanding the different particular roles of this protein is essential.
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