Planning and Scheduling of Production System in Conditioning Line: Industrial Application, Optimizationand Simulation Approach

Received: 3 April 2019 Abstract Accepted: 30 October 2019 In this article we present an industrial application of our mathematical model that integrates planning and scheduling. Our main objective is to concretize our model and compare the reel results with the theoretical ones. Our application is realized on a conditioning line of pharmaceutical products at the ECAM EPMI production laboratory. For this reason and to save time, we used Witness simulation tool. It gives an overall idea of how the line works, the Makespan of each simulation and it highlights areas for improvement. We looked for the best resulting sequence which corresponds to the minest Makespan and total production cost. Then this sequence is applied on the conditioning line of pharmaceutical products for simulation. On the other hand, we program our mathematical model with the parameters of the conditioning line under python in version 3.6 and we adopt a simulation/optimization coupling approach to verify our model.