Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms

Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell division off balance. Communication of these complex mechanisms in an engaging way often presents a challenge in a large introductory course with students from varied backgrounds and at distinct knowledge levels. We present a mixed active learning approach to facilitate student understanding of how mutation-mediated disruptions in cell cycle regulation can lead to the development of lung cancer. This lesson includes a case-based scenario, a card game about cell cycle checkpoints, mutations, and disrupted mechanisms in cancer, a problem-solving worksheet about mutations, and several electronic audience response questions interspersed throughout to monitor student progress. Through assessment of student content knowledge and perceptions, we have found this lesson to be an effective, engaging, and enjoyable way for students to learn about the molecular mechanisms underlying cancer development. Mastery – p53 Mutation Worksheet; S6. Metastatic Mastery – In-class Presentation; S7. Metastatic Mastery – Pre-Post Assessment; and S8. Metastatic Mastery – Student Perceptions Survey