Binary Mixture of Pharmaceutical Residual Solvents and Their Thermodynamic Investigation

Molecular interaction of pharmaceutical residual solvents mixture (2-Butanol with m-Xylene) were studied through deep investigation on thermodynamic properties (Enthalpy, Entropy, Free energy) over the entire range of composition at temperature of 298.15 K to 323.15 K and at atmospheric pressure. Results are interpreted and reported in the light of solvation process which is referred to as the transition of molecules from their own environment. Next, the excess thermodynamic properties were calculated, and these excess properties were fitted by the Redlich–Kister polynomial equation. The calculated excess properties are discussed in terms of molecular interactions between 2-Butanol and m-Xylene.