«Storm» of soluble differentiation molecules in COVID-19

The review presents data on changes in the content, on the prognostic and monitoring significance of soluble differentiation molecules of immune system cells in COVID-19. Among them are soluble differentiation molecules mediating innate immune responses, soluble differentiation molecules that are activation markers of lymphocytes, soluble markers of endothelial dysfunction, soluble forms of adhesion molecules, soluble differentiation molecules related to immune response checkpoints. At development of COVID-19 in blood of patients the level of the soluble molecules CD14, CD25, CD163, TREM-1, CD177, ST-2, RAGE, ICAM-1, P- and E-selectin, 14 soluble control points of the immune response including HLA-G dramatically increases. The level of soluble CD26 molecules, on the contrary, decreases. Changing the level of soluble differentiation molecules has monitoring and prognostic significance. The ideas about the <> of soluble differentiation molecules in the severe course of COVID-19 were formulated, complementing the ideas about the <>. Copyright © 2022 Meditsina Publishers. All rights reserved.