M. Hoenigl, M. F. de Oliveira, Josué Pérez-Santiago, Yonglong Zhang, S. Woods, M. Finkelman, S. Gianella
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引用次数: 20
摘要
我们评估了41名慢性hiv感染的病毒学抑制患者血液中BDG水平和其他炎症生物标志物之间的关系。我们发现BDG与neopterin水平之间存在显著相关性(r=0.68)，并且与其他炎症标志物(肿瘤坏死因子-α: r=0.30;interleukin-8: r = 0.30;白细胞介素- 6:r = 0.28)。总之，在一个病毒学抑制的慢性HIV感染个体队列中，BDG水平与炎症标志物相关。未来的研究需要评估BDG是否可能是慢性HIV感染发病率的一个标志。
Correlation of (1→3)-β-D-glucan with other inflammation markers in chronically HIV infected persons on suppressive antiretroviral therapy
We evaluated associations between levels of BDG and other biomarkers of inflammation in blood from 41 virologically suppressed persons with chronic HIV-infection. We found a significant correlation between BDG and neopterin levels (r=0.68), and trends to significance for correlations with other inflammation markers (tumor-necrosis-factor-α: r=0.30; interleukin-8: r=0.30; interleukin-6: r=0.28). In conclusion, BDG levels correlated with inflammation markers in a cohort of virologically suppressed individuals with chronic HIV infection. Future studies are needed to evaluate whether BDG may be a marker for morbidity in chronic HIV infection.
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