微生物群在COPD发病机制中的作用及其对病程的影响

Vasilii D. Fedotov, A. V. Zhestkov, A. Lyamin, M. I. Zaslavskaya, I. Dobrotina, A. Tulichev
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引用次数: 1

摘要

慢性阻塞性肺疾病(COPD)是影响全球健康的一个严重问题。感染因子在COPD恶化的发展中起主要作用。下呼吸道细菌定植在稳定期COPD患者中很常见。微生物群和宿主对潜在病原体的免疫反应的作用尚未得到很好的研究。慢性阻塞性肺病患者可发现呼吸道微生物群组成紊乱,并与肺部免疫系统的不适应变化和炎症水平增加有关。本文综述了微生物群在COPD发病机制中的作用及其对病程的影响。还讨论了肺炎球菌疫苗接种和呼吸道病原菌耐药性等重要问题。
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Microbiota in the pathogenesis of COPD and its impact on the course of the disease
Chronic obstructive pulmonary disease (COPD) is a serious problem for global health. Infectious agents play a main role in the development of COPD exacerbations. Bacterial colonization of the lower respiratory tract is common in patients with stable COPD. The role of microbiota and host immune response to potential pathogens is not well studied. Microbiota composition disorders in respiratory tract are found in patients with COPD and associated with maladaptive changes in the immune system of the lungs and increased level of inflammation. This review investigates role of microbiota in the pathogenesis of COPD and its impact on the course of the disease. Some important issues such as pneumococcal vaccination and antimicrobial resistance of respiratory pathogens are also discussed.
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