接受新辅助化疗的IIIA期和IIIB期非小细胞肺癌患者黄嘌呤氧化还原酶活性与BRCA1水平的关系

Q4 Medicine Journal of Oncological Sciences Pub Date : 2020-01-01 DOI:10.37047/jos.2019-71890

S. Yalçın, A. Sezer, A. Sümbül, Samet Rahatli, Ö. Altundağ, A. M. Sedef, O. Ozyılkan

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摘要

许多生物标志物已成为非小细胞肺癌的预后和预测标志物。其中，常见的生物标志物有表皮生长因子受体(EGFR)、核苷酸切除修复5内切酶(ERCC1)、原癌基因Kirsten肉瘤病毒(K-ras)、核糖核苷酸还原酶调节亚基。此外，大量证据表明，NSCLC与BRCA1、xor之间可能存在预后差异

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Relationship Between Xanthine Oxidoreductase Activity and BRCA1 Levels in Patients with Stage IIIA and IIIB Non-Small Cell Lung Cancer Being Treated with Neoadjuvant Chemotherapy

Many biomarkers have emerged as prognostic and predictive markers for NSCLC. Among them, the common biomarkers are the epidermal growth factor receptor (EGFR), 5 endonuclease enzyme of nucleotide excision repair (ERCC1), Kirsten sarcoma virus, which is a proto-oncogene (K-ras), and regulator subunit of ribonucleotide reductase. Besides, there is huge evidence suggesting that there might be a prognosis between NSCLC and BRCA1, XOR.1-3

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