肺腺癌患者血型与表皮生长因子受体突变阳性的关系

Q4 Medicine Journal of Oncological Sciences Pub Date : 2021-01-01 DOI:10.37047/JOS.2020-79248

M. Gürbüz, E. Akkuş, Bilgin Karaalioğlu, E. Aktaş, E. B. Köksoy, Hilal Özakıncı, S. Hayme, Y. Urun, S. Sak, A. Demirkazık, G. Utkan

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引用次数: 0

摘要

EGFR是肺腺癌的重要治疗靶点口服酪氨酸激酶抑制剂(TKIs)可用于EGFR驱动突变的患者，在西方人群中约1015%的NSCLC患者中观察到EGFR突变，在亚洲人群中高达50%。6,7在先前的一项研究中，在499例腺癌中，EGFR突变率女性为33.9%，男性为9.4%，总体突变率为14% 8此外，EGFR突变更常见于女性患者和非吸烟者

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients

EGFR is an important therapeutic target in lung adenocarcinoma.4 Oral tyrosine kinase inhibitors (TKIs) can be used in patients with driver mutations in EGFR.5 EGFR mutations were observed in ~1015% of NSCLC patients in Western populations and up to 50% in Asian populations.6,7 In a previous study, the EGFR mutation rate in adenocarcinomas was 33.9% for women and 9.4% for men in 499 cases, and the overall mutation rate was 14%.8 Also, EGFR mutations are more frequently detected in female patients and non-smokers.9

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