I. Cil, Abdilkerim Oyman, S. Isik, M. Ayhan, I. Ökten, Mustafa YILMAZ, Melike Özçelik
{"title":"胆道肿瘤切除术预后因素及细胞角蛋白20表达的影响","authors":"I. Cil, Abdilkerim Oyman, S. Isik, M. Ayhan, I. Ökten, Mustafa YILMAZ, Melike Özçelik","doi":"10.37047/jos.2021-84414","DOIUrl":null,"url":null,"abstract":"125 Biliary tract cancers (BTC) are a group of malignant tumors originating from the bile duct epithelium and include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder carcinoma (GBC).1,2 They constitute 0.7% of all cancers and 3% of all gastrointestinal cancers; approximately 250,000 new patients were diagnosed in 2020.3-5 Unfortunately,70% of BTCs are unresectable at the time of diagnosis, and their 5-year survival rate ranges from 5% to 15%.6,7 Although surgery being the only definitive treatment, R0 resection is possible in only 70% of patients. Moreover, the median overall survival (OS) duration of operated patients is less than 5 years despite the usage of modern surgical methods and adjuvant therapies.8","PeriodicalId":31838,"journal":{"name":"Journal of Oncological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic Factors in Resected Biliary Tract Cancers and the Impact of Cytokeratin 20 Expression\",\"authors\":\"I. Cil, Abdilkerim Oyman, S. Isik, M. Ayhan, I. Ökten, Mustafa YILMAZ, Melike Özçelik\",\"doi\":\"10.37047/jos.2021-84414\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"125 Biliary tract cancers (BTC) are a group of malignant tumors originating from the bile duct epithelium and include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder carcinoma (GBC).1,2 They constitute 0.7% of all cancers and 3% of all gastrointestinal cancers; approximately 250,000 new patients were diagnosed in 2020.3-5 Unfortunately,70% of BTCs are unresectable at the time of diagnosis, and their 5-year survival rate ranges from 5% to 15%.6,7 Although surgery being the only definitive treatment, R0 resection is possible in only 70% of patients. Moreover, the median overall survival (OS) duration of operated patients is less than 5 years despite the usage of modern surgical methods and adjuvant therapies.8\",\"PeriodicalId\":31838,\"journal\":{\"name\":\"Journal of Oncological Sciences\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oncological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37047/jos.2021-84414\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oncological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37047/jos.2021-84414","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Prognostic Factors in Resected Biliary Tract Cancers and the Impact of Cytokeratin 20 Expression
125 Biliary tract cancers (BTC) are a group of malignant tumors originating from the bile duct epithelium and include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder carcinoma (GBC).1,2 They constitute 0.7% of all cancers and 3% of all gastrointestinal cancers; approximately 250,000 new patients were diagnosed in 2020.3-5 Unfortunately,70% of BTCs are unresectable at the time of diagnosis, and their 5-year survival rate ranges from 5% to 15%.6,7 Although surgery being the only definitive treatment, R0 resection is possible in only 70% of patients. Moreover, the median overall survival (OS) duration of operated patients is less than 5 years despite the usage of modern surgical methods and adjuvant therapies.8