体外实验显示中药复合物对弯血螨有驱虫作用

IF 3.8 3区农林科学 Q1 VETERINARY SCIENCES Pakistan Veterinary Journal Pub Date : 2020-04-01 DOI:10.29261/pakvetj/2019.128

M. Zaman

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引用次数: 8

摘要

收到:修订:接受:在线发布:2019年10月8日2019年12月9日2019年12月24日2019年12月31日在耐药性时代，新的药用植物正在被评估用于控制寄生虫。本文研究了由四种草本植物组成的中药复合物(HC)提取物(Origanum vulgare、Cinnamomum verum、Rosmarinus officinalis和Capsicum annuum)对弯血螨(Haemonchus contortus)卵和成虫的驱虫活性。采用卵孵化试验(EHT)和成虫运动试验(AMA)评价HC的驱虫潜能。EHT的对照药物为奥芬达唑，AMA的对照药物为奥芬达唑(2.265 mg ml)和左旋咪唑(3mg ml)。在EHT中，HC和奥芬达唑的LC50值分别为498和1.6 ppm。在AMA中，HC (100 mg ml)处理6小时后，观察到弯曲螺旋体的死亡率为100%，而两个阳性对照组在此暴露时间后不能杀死所有蠕虫。这些结果表明了HC的驱虫潜力。©2019 PVJ。版权所有

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In vitro Experiments Revealed the Anthelmintic Potential of Herbal Complex against Haemonchus contortus

Received: Revised: Accepted: Published online: October 8, 2019 December 9, 2019 December 24, 2019 December 31, 2019 In an era of drug resistance, new medicinal plants are being evaluated for control of parasites. In the present study, the anthelmintic activity of the extract of herbal complex (HC) composed of four herbs (Origanum vulgare, Cinnamomum verum, Rosmarinus officinalis and Capsicum annuum) was assessed against eggs and adult Haemonchus (H.) contortus. Egg hatch test (EHT) and adult motility assay (AMA) was performed to evaluate the anthelmintic potential of HC. The reference drug used in EHT was oxfendazole and for AMA two drugs i.e. oxfendazole (2.265 mg ml) and levamisole (3mg ml) were used. In EHT, LC50 values of HC and oxfendazole were 498 and 1.6 ppm, respectively. In AMA, 100% mortality of H. contortus was observed after 6 hr of treatment with HC (100 mg ml) where as two positive control groups could not kill all worms after this exposure time. These results indicated the anthelmintic potential of HC. ©2019 PVJ. All rights reserved

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来源期刊

Pakistan Veterinary Journal 兽医-兽医学

CiteScore

4.20

自引率

13.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Pakistan Veterinary Journal (Pak Vet J), a quarterly publication, is being published regularly since 1981 by the Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan. It publishes original research manuscripts and review articles on health and diseases of animals including its various aspects like pathology, microbiology, pharmacology, parasitology and its treatment. The “Pak Vet J” (www.pvj.com.pk) is included in Science Citation Index Expended and has got 1.217 impact factor in JCR 2017. Among Veterinary Science Journals of the world (136), “Pak Vet J” has been i) ranked at 75th position and ii) placed Q2 in Quartile in Category. The journal is read, abstracted and indexed internationally.