双肺移植后胸壁硬纤维瘤

Matthew P. Fahrenkopf, John P. Kelpin, Edward Murphy, E. Komorowska‐Timek
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引用次数: 2

摘要

硬纤维瘤对治疗医生提出了许多独特的挑战。它们具有不可预测的临床病程、侵袭性和切除后复发的倾向。它们经常在以前的创伤区域发展,也被认为对激素刺激敏感。保守治疗通常被推荐为主要的治疗选择。对于有症状和/或病变逐渐扩大的患者,手术是必要的。完全切除通常被认为是“金标准”,但外科医生应始终考虑最小化发病率和最大化功能。文献中描述实体器官移植后硬纤维瘤的报道数量有限。在此,我们报告一位66岁的男士,在肺移植两年后发现右胸壁有肿块。患者最初通过一系列放射成像进行监测。快速生长促使组织活检,发现一个硬纤维瘤。病变持续扩大并侵入周围的骨皮结构需要手术干预。整块切除肿块并立即重建胸壁。移植后发生的新病变必须仔细监测。硬纤维瘤虽然罕见,但在鉴别诊断中应予以考虑。早期诊断可以通过减少切除的范围来降低患者的发病率。
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Chest wall desmoid tumor after double lung transplantation
Desmoid tumors pose a number of unique challenges to treating physicians. They have an unpredictable clinical course, aggressive nature, and predilection for recurrence after resection. They frequently develop in areas of previous trauma and have also been thought to be sensitive to hormonal stimuli. Conservative management is often recommended as a primary therapeutic option. Surgery becomes necessary for those patients with symptomatic and/or progressively enlarging lesions. Complete resection is often considered the “gold standard”, but surgeons should always consider minimizing morbidity and maximizing function. There are a limited number of reports in the literature describing desmoid tumors after solid organ transplantation. Here, we report a 66-year-old gentleman who was found to have a mass on his right chest wall two years after lung transplantation. The patient was initially monitored with serial radiographic imaging. Rapid growth prompted a tissue biopsy, revealing a desmoid tumor. Continued expansion and invasion of the lesion into the surrounding osteocutaneous structures required surgical intervention. En bloc resection of the mass with immediate chest wall reconstruction was performed. New lesions developing after transplantation must be monitored with scrutiny. Desmoid tumors, though rare, should be considered in this differential diagnosis. Early diagnosis may decrease patient morbidity by reducing the extent of resection.
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