Clinical and morphological aspects of the reproductive system of reproductive age women with menstrual disorders after COVID-19

Objective: to study the structural and metabolic features of endometrial structure in reproductive age women with menstrual disorders after COVID - 19 and to determine the correlation between histological status and parameters of endometrial morphometry in this group of patients. Materials and methods. Bibliographic, information-analytical, clinical-instrumental, laboratory, histomorphological methods were used in the work. Sources of information were data from the scientific literature on the topic of the study, modern gadleins, a review of randomized controlled trials. Results and discussion. Menstrual disorders such as menometrorrhagia is one of the main reasons for seeking medical help and hospitalization. A significant role of the menometrorrhagia development belongs to the disruption of hormonal homeostasis with changes in the growth and differentiation of cellular elements of the endometrium. Stressors can activate the hypothalamic-pituitary-gonadal axis (HPG axis) and alter the neuromodulatory cascade that controls the regulation of gonadotropin-releasing hormone (GnRH). In addition gonadotropin-releasing hormone (GnRH) may play a role in the autocrine regulator of carcinoma cell line proliferation [13]. According to the WHO more than 106 million patients suffered from COVID – 19 worldwide in 2021. Fear of contracting the virus, forced social exclusion, as well as insecurities about financial stability and the future, have had a significant impact on the mental health of many people in European countries. [1,3,4]. As stress has its own characteristics for the female body we study the structural and metabolic characteristics of hyperplastic processes in reproductive age women with menstrual disorders as menometrorrhagia after COVID - 19 to improve the algorithm of examination and prediction of pathological processes of the endometrium [2,5,6,7]. Conclusions. The described histological picture indicates the presence of asynchrony of the processes of secretory transformation of the endometrium into the luteal phase of the MC. The period of endometrial monitoring in patients of reproductive age with menstrual irregularities by type of menometrorrhagia after COVID-19 should be at least 3-6 months after surgery, as a probable increase in the risk of recurrence of GE over time.