过早染色体凝聚法剂量评定校正曲线的构建

Q4 Biochemistry, Genetics and Molecular Biology Genome Integrity Pub Date : 2016-01-01 DOI:10.4103/2041-9414.197166
E. Neronova
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引用次数: 8

摘要

细胞遗传学剂量学在放射事故/事故中受影响人群的分类和医疗管理中发挥着重要作用。细胞遗传学生物剂量学使用不同的方法来估计暴露个体的吸收剂量,每种方法都有其优点和缺点。早染色体凝聚(PCC)分析有几个优点,有望填补其他细胞遗传学方法的空白。为了将该技术引入到其他细胞遗传学方法中,我们为实验室生成了γ辐照后PCC的校准曲线。
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Construction of Calibration Curve for Premature Chromosome Condensation Assay for Dose Assessment
Cytogenetic dosimetry plays an important role in the triage and medical management of affected people in radiological incidents/accidents. Cytogenetic biodosimetry uses different methods to estimate the absorbed dose in the exposed individuals, and each approach has its advantages and disadvantages. Premature chromosome condensation (PCC) assay presents several advantages that hopefully fulfill the gaps identified in the other cytogenetic methods. To introduce this technique into the panel of other cytogenetic methods, a calibration curve for PCC after γ-irradiation was generated for our laboratory.
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Genome Integrity
Genome Integrity Biochemistry, Genetics and Molecular Biology-Genetics
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