国内22个实验室细胞遗传学剂量学比较

Q4 Biochemistry, Genetics and Molecular Biology Genome Integrity Pub Date : 2016-01-01 DOI:10.4103/2041-9414.197164
Jian Xiang Liu, Yan Pan, Jian-lei Ruan, Chunnan Piao, Xu Su
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引用次数: 4

摘要

在中国国家卫生和计划生育委员会的支持下,作为国际原子能机构协调的区域研究项目的一部分,22个实验室参加了中国细胞遗传剂量学的相互比较。染色体畸变的幻灯片是由组织这次演习的国家放射防护研究所辐射流行病学部制作的。投影片已透过特快专递服务寄往其他参与实验所。对于剂量的估计,每个实验室对双中心染色体加中心环染色体的频率进行评分。用60Co γ射线(1.3 Gy、2.4 Gy和1.5 Gy、2.6 Gy)照射全血。每个实验室有一组载玻片。44个剂量估计值中有10个在真实物理剂量的±5%范围内,12个在±5-10%范围内,9个在±10-15%范围内,12个在±15-20%范围内,而只有一个样本在±>20%范围内。21个实验室对各自的剂量进行了评估。
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Intercomparison in Cytogenetic Dosimetry among 22 Laboratories in China
As part of a regional International Atomic Energy Agency-coordinated research project with the support from the National Health and Family Planning Commission of China, 22 laboratories participated in the intercomparison in cytogenetic dosimetry in China. Slides for chromosomal aberrations were prepared by the Department of Radiation Epidemiology, National Institute for Radiological Protection, which organized the exercise. Slides were sent to the other participating laboratories through Express Mail Service. For estimates of dose, each laboratory scored the frequency of dicentrics plus centric rings chromosomes. The whole blood samples were irradiated with 60Co γ-rays (1.3 Gy, 2.4 Gy and 1.5 Gy, 2.6 Gy). Each laboratory got one group of the slides. Ten of the 44 estimates of dose fell within ±5% of the true physical dose, 12 fell within ±5–10%, 9 fell within ±10–15%, 12 fell within ±15–20%, while only one sample fell ± >20%. The evaluation of the respective dose was achieved by 21 laboratories.
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来源期刊
Genome Integrity
Genome Integrity Biochemistry, Genetics and Molecular Biology-Genetics
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