软骨IIB型前胶原nh2前肽,PIIBNP,抑制血管生成

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY AIMS Molecular Science Pub Date : 2021-01-01 DOI:10.3934/molsci.2021022
Zhepeng Wang, Aiwu Lu
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引用次数: 0

摘要

软骨组织无血管,抗肿瘤侵袭,但这些特性的基础尚不清楚。本文报道了IIB型前胶原的nh2 -前肽(PIIBNP)是胶原生物合成的产物,在体外和体内都能抑制血管生成。PIIBNP抑制人脐静脉细胞(HUVEC)的管状形成,在小鼠主动脉环血管生成生物实验中抑制内源性内皮细胞的生长,在小鼠角膜血管生成实验中具有抗血管生成作用。由于αVß3和αVß5整合素主要在内皮细胞、癌细胞和破骨细胞中表达,而在正常软骨细胞中不表达,并且PIIBNP与细胞表面整合素αVß3和αVß5结合,我们提出天然存在的PIIBNP在软骨形成过程中通过靶向内皮细胞来保护软骨,从而抑制血管生成,使组织无血管。
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Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis

Cartilage tissue is avascular and resistant to tumor invasion, but the basis for these properties is still unclear. Here we report that the NH2-propeptide of type IIB procollagen (PIIBNP), a product of collagen biosynthesis, is capable of inhibiting angiogenesis both in vitro and in vivo. PIIBNP inhibits tube formation in human umbilical vein cells (HUVEC), inhibits endogenous endothelial cell outgrowth in mouse aortic ring angiogenesis bioassay and is anti-angiogenic in the mouse cornea angiogenesis assay. As αVß3 and αVß5 integrins are expressed primarily in endothelial cells, cancer cells and osteoclasts, but not in normal chondrocytes and PIIBNP binds to cell surface integrin αVß3 and αVß5, we propose that natural occurring PIIBNP protects cartilage by targeting endothelial cells during chondrogenesis, thus inhibiting angiogenesis, and rendering the tissue avascular.

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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
4
审稿时长
5 weeks
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