量子磁共振疗法:针对生物物理癌症脆弱性有效治疗和缓解

Ranjit Kumar, M. Augustus, A. Nair, R. Ebner, G. Nayar, Rajah Vijay Kumar
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引用次数: 24

摘要

背景:传统思维的彻底转变对于赢得与癌症的战争和理解为什么这种疾病即使在最残酷的有毒疗法下仍然存在至关重要。越来越多的证据表明,生物物理信号在癌细胞的发生、发展和死亡的周期中是不可或缺的。在实体瘤中操纵这种脆弱性的创新技术可以有效地用于干扰病变细胞和组织。在控制肿瘤进展的同时不损害正常功能的细胞,是量子磁共振疗法等癌症治疗方法的最终目标,它在这个方向上很有希望。方法:获得专利的CE标记设备,CYTOTRON®在集成的瞬时磁场存在下提供旋转,特定目标,调制,安全的无线电频率。旋转场量子磁共振平台技术推测了肿瘤细胞跨膜电位和射频下游细胞信号传导在癌症组织变性中的调节作用。用于组织质子密度测定的全身MRI用于计算个体化剂量,同时针对整个身体的单个或多个感兴趣的区域。QMRT暴露时间为每天1小时,连续28天。使用RECIST v1.1进行生活质量评估、总生存期和肿瘤稳定性随访12个月。结果:预期寿命从预测到实际平均显著增加(p=2.13 E-12), Karnofsky绩效量表评分(p=7.25 E-06)和生活质量评分(p=1.71 E-08和p=1.91 E-06)均有改善。51例晚期患者中有36例(71%)在QMRT完成一个月或更长时间后病情稳定。结论:暴露于射频介导的QMRT可改善预期寿命和生活质量,同时抑制肿瘤进展。这种疗法可以安全地定位在姑息治疗环境中,通过更严格的临床验证过渡到主流癌症治疗。
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Quantum Magnetic Resonance Therapy: Targeting Biophysical Cancer Vulnerabilities to Effectively Treat and Palliate
Background: Radical paradigm shifts in traditional thinking is paramount to winning the war on cancer and understanding why this disease survives even the most brutal of toxic therapies. There is mounting evidence that biophysical signals are integral to the cycle of initiation, progression and death of cancer cells. Innovative technologies that manipulate this vulnerability in solid tumors could effectively be used to perturb only diseased cells and tissues. Not compromising normally functioning cells while controlling tumor progression, is the ultimate goal for evolving cancer therapeutics like Quantum Magnetic Resonance Therapy, headed promisingly in that direction. Methods: A patented, CE marked device, the CYTOTRON® delivers rotating, target-specific, modulated, safe Radio Frequencies in the presence of an integrated, instantaneous magnetic field. The presumed modulation of the transmembrane potential of tumor cells and downstream cellular signalling by RF for tissue degeneration in cancer underlies Rotational Field Quantum Magnetic Resonance platform technology. Whole body MRI for tissue proton density determinations was used to compute individualized dosimetry to target solitary or multiple regions of interest in the whole body, simultaneously. Exposure to QMRT was for 1 hour daily for 28 consecutive days. Quality of Life assessments, overall survival and tumor stability using RECIST v1.1 were followed up for 12 months. Results: Significant increase in life expectancy from the predicted to the actual mean (p=2.13 E-12), and improvements in Karnofsky Performance Scale scores (p=7.25 E-06) and Quality of Life scores (p=1.71 E-08 and p=1.91 E-06) were noted. Thirty six of 51 (71 %) terminally ill patients had stable disease one month after completion of QMRT or longer. Conclusions: Exposure to radiofrequency-mediated QMRT improved life expectancy and quality of life, along with arrest of tumor progression. This therapy can be safely positioned in a palliative care setting, transitioning to mainstream cancer care with more rigorous clinical validation.
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