毛缕草乙醇提取物对小反刍动物成虫胃肠道蛔虫的原位驱虫活性评价

M. Gertrude, Yondo Jeannette, T. Gabriel, M. Mbida
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引用次数: 1

摘要

胃肠道线虫引起的感染是发展中国家畜牧业面临的主要威胁。它们以生产损失的形式造成直接影响,并因驱虫药价格高昂而造成间接经济损失。在实践中有各种替代策略来控制寄生,其中包括使用药用植物。本研究评价了毛缕草乙醇提取物对小反刍动物胃肠道细胞的原位驱虫活性。将自然感染山羊20只(20只)分为5组(n = 4),分别给予Tween 80(2.8%)、阿苯达唑(5 mg/kg)和提取物(125、250和500 mg/kg) 3个剂量。提取液和2.8% Tween 80剂量每日两次,连续3天,阿苯达唑单剂量给药。测定粪卵减少量、体重、堆积细胞体积(PCV)和总虫数减少量。结果表明,毛蕊双歧杆菌乙醇提取物对成虫无抑制作用,而阿苯唑可使消化圈虫卵数和虫总数减少100%。体重和PCV几乎保持不变。本研究表明,在试验剂量下,毛缕草乙醇提取物没有驱虫活性。然而,进一步优化和规范其乙醇提取物可以增强其驱虫活性。
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Assessment of in Situ Anthelminthic Activity of Ethanolic Extract of Bidens pilosa against Adult’s Gastro-Intestinal Strongyle of Small Ruminants
Infections caused by gastrointestinal nematodes are major threats to livestock industry in the developing countries. They cause direct effects in form of loss in production and indirect economic losses due to high cost of anthelmintic drugs. Various alternative strategies are in practice to control parasitism which includes the usage of medicinal plants. This study evaluates the in situ anthelminthic activity of Bidens pilosa ethanolic extract on gastro-intestinal strongyles of small ruminants. Twenty (20) naturally infested goats of both sexes were distributed into 5 groups (n = 4) corresponding to groups receiv-ing Tween 80 at 2.8%, Albendazole at 5 mg/kg and the three doses of extract (125, 250 and 500 mg/kg). The doses of extract and 2.8% Tween 80 were administered twice daily for 3 consecutive days while Albendazole was administered in a single dose. Faecal eggs count reduction, body weight, packed cell volume (PCV) and total worm count reduction were determined. Results showed that the ethanolic extract of B. pilosa was not effective against adult worms while Albendozole inflicted a 100% reduction of eggs count and total worm count of digestive strongyle. Body weight and PCV remain almost con-stant. This study indicates that ethanolic extract of B. pilosa at tested doses has no anthelminthic activity. However, further optimization and standardization of the ethanolic extract of B. pilosa could enhance its anthelminthic activity.
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