Insights on biomarkers from Chinese hamster ovary omics studies

As efforts for selecting high-producing cells during cell line development are moving toward the use of high-throughput, automated methods, there is considerable promise for identifying suitable markers arising from transcriptomic, proteomic and metabolomic studies. Herein we discuss the opportunities presented from recent characterization studies of high producers as well as comparisons with non- and lower-producing clones. We further put forward unique characteristics of cell lines with high productivity, which can be used for cell line screening and genetic engineering.