结节性硬化症的严重神经系统受累:两例报告及非洲文献综述

IF 0.1 African Journal of Neurological Sciences Pub Date : 2008-08-22 DOI:10.4314/AJNS.V26I2.7604

I. Lagunju, C. Okolo, Be Ebruke, K. Emejulu, A. Malomo, E. Akang, M. Shokunbi

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引用次数: 3

摘要

结节性硬化症(TS)是一种以皮肤病变、癫痫和智力迟钝为特征的遗传性疾病。已知TS具有广泛的临床范围，一些患者只有皮肤表现，智商正常，没有癫痫发作，而另一些患者则严重影响顽固性癫痫发作和深度智力迟钝。本文介绍了在尼日利亚伊巴丹大学学院医院管理的两名患有TS的尼日利亚儿童的报告。两人都有严重的神经系统症状，其中一人的一级亲属有亚临床症状。非洲神经科学杂志Vol. 26 (2) 2007: pp. 102-108

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Severe Neurological Involvement In Tuberous Sclerosis: A Report Of Two Cases And A Review Of The African Literature

Tuberous sclerosis (TS) is a genetic disorder characterised by the triad of cutaneous lesions, epilepsy and mental retardation. TS is known to have a wide clinical spectrum, with some affected individuals having only the cutaneous manifestations, normal IQ and no seizures, while others are severely affected having intractable seizures and profound mental retardation. A report of two Nigerian children with TS managed at the University College Hospital, Ibadan, Nigeria is presented. Both had severe neurological manifestations of the disease and a sub clinical affectation was found in a first degree relative in one of them. African Journal of Neurological Sciences Vol. 26 (2) 2007: pp. 102-108

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