{"title":"体外浓缩机制由2-乙基-3-O-磺酰基-雌二醇-1,3,5（10），15-四烯-3-醇-17-酮与“二氯asetyl管”联合作用于乳腺腺癌细胞（MCF-7）和乳腺非肿瘤细胞（MCF-12A）来确定","authors":"X. X. Stander, A. Stander, A. Joubert","doi":"10.4102/SATNT.V31I1.343","DOIUrl":null,"url":null,"abstract":"2-Etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17 (C9) is ‘n nuwe,in silico-ontwerpte, antimitotiese 17-beta-estradiolderivaat. Dichloro-asetielsuur (DCA) inhibeer pirovaat dehydrogenase kinase ensiem aktiwiteit wat die vorming en vervoer van asetiel-KoA in die mitochondria inhibeer. Dit veroorsaak dat fermentasie prosesse, wat in kankerselle bevoordeel word, onderdruk word.","PeriodicalId":30428,"journal":{"name":"South African Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2012-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4102/SATNT.V31I1.343","citationCount":"0","resultStr":"{\"title\":\"In vitro seintransduksie meganisme uitgeoefen deur 2-etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17-een in kombinasie met ‘n dichloro-asetielsuur op die bors adenokarsinoom (MCF-7) en bors nie-tumorigene (MCF-12A) selle\",\"authors\":\"X. X. Stander, A. Stander, A. Joubert\",\"doi\":\"10.4102/SATNT.V31I1.343\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"2-Etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17 (C9) is ‘n nuwe,in silico-ontwerpte, antimitotiese 17-beta-estradiolderivaat. Dichloro-asetielsuur (DCA) inhibeer pirovaat dehydrogenase kinase ensiem aktiwiteit wat die vorming en vervoer van asetiel-KoA in die mitochondria inhibeer. Dit veroorsaak dat fermentasie prosesse, wat in kankerselle bevoordeel word, onderdruk word.\",\"PeriodicalId\":30428,\"journal\":{\"name\":\"South African Journal of Science and Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4102/SATNT.V31I1.343\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"South African Journal of Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/SATNT.V31I1.343\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Journal of Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/SATNT.V31I1.343","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vitro seintransduksie meganisme uitgeoefen deur 2-etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17-een in kombinasie met ‘n dichloro-asetielsuur op die bors adenokarsinoom (MCF-7) en bors nie-tumorigene (MCF-12A) selle
2-Etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17 (C9) is ‘n nuwe,in silico-ontwerpte, antimitotiese 17-beta-estradiolderivaat. Dichloro-asetielsuur (DCA) inhibeer pirovaat dehydrogenase kinase ensiem aktiwiteit wat die vorming en vervoer van asetiel-KoA in die mitochondria inhibeer. Dit veroorsaak dat fermentasie prosesse, wat in kankerselle bevoordeel word, onderdruk word.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
