抑制细胞死亡：线粒体与 IκΒα 之间意想不到的联系。

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2022-01-11 eCollection Date: 2021-01-01 DOI:10.4161/23723556.2014.995020

Evangelos Pazarentzos

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引用次数: 0

摘要

IκΒα（NFKBIA 基因的蛋白产物）由于能够抑制抗凋亡转录因子 NFκB 而被广泛认为是一种促凋亡因子。我们的研究结果表明，IκΒα 在线粒体外膜（OMM）上也具有很强的抗凋亡活性。我们发现的这一功能不同于它封存和抑制 NFκB 的能力。IκΒα 与电压依赖性阴离子通道 1（VDAC1）和六激酶 2（HK2）结合，稳定这一复合物并防止线粒体外膜渗透（MOMP）和细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα.

IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activity at the outer mitochondria membrane (OMM). This function we uncovered is distinct from its ability to sequester and inhibit NFκB. IκΒα instead binds to voltage dependent anion channel 1 (VDAC1) and Hexokinase 2 (HK2), stabilizes this complex and prevents mitochondria outer membrane permeabilisation (MOMP) and apoptosis.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.