microrna介导的神经干细胞/祖细胞神经原性向胶质原性转变的调控

H. Naka-Kaneda, T. Shimazaki, H. Okano
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引用次数: 1

摘要

在中枢神经系统(CNS)发育过程中,多能性神经干细胞/祖细胞(NSPCs)产生多种类型的神经元和胶质细胞;然而,NSPCs并不总是能够产生所有类型的神经细胞。复杂神经网络的形成依赖于NSPCs的适当细胞发生,这一过程受到内外机制的严格时空调控。神经发生到胶质瘤发生的转换是中枢神经系统发育过程中的一个重要事件,在很大程度上取决于NSPCs的细胞自主时间规范。先前的一些研究结果表明,发育阶段依赖性的前体细胞和星形细胞基因的表观遗传状态变化与发育中的NSPCs的时间身份转变有关。这些变化与NSPCs对外源性神经源性或胶质源性因子的反应性改变有关。在这里,我们讨论了我们最近的发现,即microrna介导的能力调控和多层分子调控系统之间的关系控制了中枢神经系统发育过程中NSPCs的时间规范。
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MicroRNA-mediated regulation of the neurogenic-to-gliogenic competence transition of neural stem/progenitor cells
Multipotent neural stem/progenitor cells (NSPCs) produce various types of neurons and glial cells during the development of the central nervous system (CNS); however, NSPCs are not always able to generate all types of neural cells. The formation of complex neural networks relies on proper cytogenesis from NSPCs, which is under strict spatiotemporal regulation by intrinsic and extrinsic mechanisms. The neurogenesis-to-gliogenesis switch, a major event during CNS development, is largely dependent on the cell-autonomous temporal specification of NSPCs. The results of several previous studies suggest that developmental stage-dependent changes in the epigenetic status of proneural and astrocytic genes correlate with the temporal identity transition of developing NSPCs. These changes are related to alterations in the responsiveness of NSPCs to extrinsic neurogenic or gliogenic factors. Here, we discuss our recent findings that microRNA-mediated regulation of competence and relationships between multi-layered molecular regulatory systems control the temporal specification of NSPCs during CNS development.
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