Majd Farajallah, Fatima Alkaabi, Arif Alam, Raya Almazrouei
{"title":"9q34缺失细胞遗传学异常的急性髓系白血病中继性尿崩症。","authors":"Majd Farajallah, Fatima Alkaabi, Arif Alam, Raya Almazrouei","doi":"10.5001/omj.2024.22","DOIUrl":null,"url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is rarely associated with central diabetes insipidus (CDI) with unclear underlying pathophysiological mechanisms. The most commonly reported cytogenetic abnormality in cases of AML-associated CDI is monosomy 7, followed by chromosome 3 abnormalities. We report a case of a woman with newly diagnosed AML with 9q34 deletion (<i>ABL1</i> gene region), who developed symptoms of polyuria and polydipsia with an investigation confirming CDI. This is the first reported case of cytogenetic abnormality of 9q34 deletion (<i>ABL1</i> gene region) in AML with CDI.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"52 1","pages":"e661"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694343/pdf/","citationCount":"0","resultStr":"{\"title\":\"Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion.\",\"authors\":\"Majd Farajallah, Fatima Alkaabi, Arif Alam, Raya Almazrouei\",\"doi\":\"10.5001/omj.2024.22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Acute myeloid leukemia (AML) is rarely associated with central diabetes insipidus (CDI) with unclear underlying pathophysiological mechanisms. The most commonly reported cytogenetic abnormality in cases of AML-associated CDI is monosomy 7, followed by chromosome 3 abnormalities. We report a case of a woman with newly diagnosed AML with 9q34 deletion (<i>ABL1</i> gene region), who developed symptoms of polyuria and polydipsia with an investigation confirming CDI. This is the first reported case of cytogenetic abnormality of 9q34 deletion (<i>ABL1</i> gene region) in AML with CDI.</p>\",\"PeriodicalId\":19667,\"journal\":{\"name\":\"Oman Medical Journal\",\"volume\":\"52 1\",\"pages\":\"e661\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694343/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oman Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5001/omj.2024.22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oman Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5001/omj.2024.22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion.
Acute myeloid leukemia (AML) is rarely associated with central diabetes insipidus (CDI) with unclear underlying pathophysiological mechanisms. The most commonly reported cytogenetic abnormality in cases of AML-associated CDI is monosomy 7, followed by chromosome 3 abnormalities. We report a case of a woman with newly diagnosed AML with 9q34 deletion (ABL1 gene region), who developed symptoms of polyuria and polydipsia with an investigation confirming CDI. This is the first reported case of cytogenetic abnormality of 9q34 deletion (ABL1 gene region) in AML with CDI.
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