B. Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, G. Zhusupbaeva, Orozby Akparalieva, Z. Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, G. Apryshko, Alina Orozmatova
{"title":"硅、体外和体内方法研究硫代氨基脲类碳水化合物衍生物的生物活性和毒性","authors":"B. Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, G. Zhusupbaeva, Orozby Akparalieva, Z. Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, G. Apryshko, Alina Orozmatova","doi":"10.4236/jacen.2022.111002","DOIUrl":null,"url":null,"abstract":"Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.","PeriodicalId":68148,"journal":{"name":"农业化学和环境(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods\",\"authors\":\"B. Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, G. Zhusupbaeva, Orozby Akparalieva, Z. Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, G. Apryshko, Alina Orozmatova\",\"doi\":\"10.4236/jacen.2022.111002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.\",\"PeriodicalId\":68148,\"journal\":{\"name\":\"农业化学和环境(英文)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"农业化学和环境(英文)\",\"FirstCategoryId\":\"1091\",\"ListUrlMain\":\"https://doi.org/10.4236/jacen.2022.111002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"农业化学和环境(英文)","FirstCategoryId":"1091","ListUrlMain":"https://doi.org/10.4236/jacen.2022.111002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
对N-(β- d -半乳糖酰基)-硫代氨基脲类化合物进行计算机分析，结果表明该化合物具有抗菌(抗细菌)、抗结核(抗结核)、抗病毒(抗流感)、抗肿瘤(抗肿瘤)9 > Pa > 0.5的高概率，具有细胞毒性/细胞毒性(细胞抑制剂/细胞毒性)活性的低概率。体外和体内实验研究表明，所研究的新合成化合物N-(β- d -半乳糖酰基)-硫代氨基脲在所研究浓度下具有明显的杀菌和抑菌作用。
Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods
Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
