继发性静脉曲张的病因研究

Kshitij Manerikar, C. Patil, S. Bhatia, Gurjit Singh, H. Gawade
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引用次数: 2

摘要

下肢静脉最容易发生静脉疾病,静脉曲张是最大的问题。静脉曲张可分为原发性和继发性静脉曲张。继发性静脉曲张与获得性因素有关,引起瘀血和高凝状态。本研究探讨继发性静脉曲张的各种相关危险因素,如年龄、性别、体重指数(BMI)、妊娠、长时间站立、吸烟、深静脉血栓形成史和继发性静脉曲张家族史。方法:2015年8月至2016年7月对50例患者进行前瞻性非随机研究。记录所有患者的人口统计细节。详细的病史和检查双下肢。描述性统计采用计量均数、标准差(SD)和95%置信区间的比例计算。结果:在我们对50例患者的研究中,任何形式的咀嚼烟草都是继发性静脉曲张最常见的相关危险因素,46%的患者出现了这种情况。我们发现静脉曲张在男性中更为常见,尤其是在50岁以上的人群中。其中肥胖患者20例,体重指数大于25kg /m2。静脉曲张的既往病史和治疗与静脉曲张患病率无显著相关性。26%的女性静脉曲张患者怀孕超过2次。结论:站立时间过长、吸烟(10支/天)、两次以上妊娠、深静脉血栓家族史是发生静脉曲张的主要危险因素。我们不能在深静脉血栓形成史和静脉曲张手术与复发之间建立任何强有力的联系。在可改变的危险因素中,咀嚼烟草和吸烟应被放弃,以减少静脉曲张的发生率。
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A study of etiology of secondary varicose veins
Introduction: Lower limb veins are most prone to having venous disorders – and varicose veins are the biggest issue. Varicose veins can be grouped into Primary or Secondary Varicose veins. Secondary Varicose veins are associated with acquired factors causing stasis and hypercoagulable state. This study addresses the various associated risk factors for secondary varicose veins such as age, sex, Body Mass Index (BMI), pregnancy, prolonged standing, tobacco use, and deep vein thrombosis history and family history of secondary varicose veins. Methods: A prospective non-randomized study of fifty patients was carried out between August 2015 and July 2016. Demographic details of all patients were recorded. Detail history and examination of both lower limbs were performed. Descriptive statistics were calculated by measuring means, standard deviation (SD), and proportions with 95% confidence interval. Results: Tobacco chewing in any form was the most common associated risk factor of secondary varicose vein in our study of 50 patients and it was observed in 46% of patients. We found that varicose veins were more common in males and it was especially predominant in the over fifty years of age. Amongst them, twenty patients were obese with body mass index of more than 25 kg/m2. Past history of varicose veins and treatment for same was not associated significantly with varicose veins prevalence. More than two numbers of pregnancies were found in 26% females with varicose veins. Conclusion: We found that prolong standing, smoking (> 10 cigarettes/day), more than two pregnancies, and family history of deep venous thrombosis were some of the major associated risk factors for varicose veins. We couldn’t establish any strong association between previous history of deep venous thrombosis and varicose vein surgery with respect to recurrence of it. Among modifiable risk factors, tobacco chewing and smoking should be abandoned to decrease the inci dence of varicose veins.
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